INT300383

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.62
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
colon 2
blood 1
MIR17 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 1 85.24 High High
Inflammation 30 74.44 Quite High
cytokine 27 63.40 Quite High
Central nervous system 31 56.88 Quite High
tolerance 5 14.08 Low Low
Multiple sclerosis 159 5.00 Very Low Very Low Very Low
Demyelination 5 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 28 99.76 Very High Very High Very High
Demyelinating Disease 236 99.00 Very High Very High Very High
Cancer 347 95.96 Very High Very High Very High
Repression 9 90.24 High High
Prostate Cancer 40 85.88 High High
INFLAMMATION 37 74.44 Quite High
Neuromyelitis Optica 2 73.76 Quite High
Disease 98 72.04 Quite High
Autoimmune Disease 51 67.12 Quite High
Recurrence 8 59.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of special interest is miR-17 which we found to be down regulated in peripheral blood.
Regulation (regulated) of miR-17 in blood
1) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920328 Disease Relevance 1.01 Pain Relevance 0.07
Bcl-6 also represses expression of many miRNAs predicted to control the T follicular cell signature, including miR-17-92, which represses CXCR5 expression.
Regulation (control) of miR-17
2) Confidence 0.04 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.24 Pain Relevance 0.10
EP300 is involved in colon and pancreatic cancer (predicted target of miR-17-5p, miR-32, miR-20a and miR-106a), and so on.
Regulation (target) of miR-17-5p in colon associated with pancreatic cancer
3) Confidence 0.04 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.23 Pain Relevance 0
For example, APC is involved in colon and pancreatic cancer and it is a predicted target of miR-17-5p, miR-32, miR-20a and miR-106a.
Regulation (target) of miR-17-5p in colon associated with pancreatic cancer
4) Confidence 0.04 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.14 Pain Relevance 0

General Comments

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