INT30040

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Context Info
Confidence 0.51
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 2.72
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYRP1)
Anatomy Link Frequency
brain 1
hippocampus 1
TYRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
TRP channel 4 100.00 Very High Very High Very High
Opioid 4 97.60 Very High Very High Very High
Potency 4 96.72 Very High Very High Very High
Hippocampus 3 95.60 Very High Very High Very High
Enkephalin 8 94.88 High High
melanocortin 1 receptor 4 89.72 High High
Inflammation 1 87.68 High High
Intracerebroventricular 1 87.04 High High
opioid receptor 8 84.32 Quite High
Pain 2 83.08 Quite High
Disease Link Frequency Relevance Heat
Hypophosphatemia 2 99.96 Very High Very High Very High
Channelopathies 1 99.34 Very High Very High Very High
Skin Cancer 5 99.12 Very High Very High Very High
Cancer 7 98.92 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 20 98.88 Very High Very High Very High
Disease 30 98.16 Very High Very High Very High
Fatigue 19 95.76 Very High Very High Very High
Rickets 3 94.12 High High
INFLAMMATION 1 87.68 High High
Microphthalmia 1 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, ASIP down-regulation of tyrp1 was observed at the translational level.
Negative_regulation (down-regulation) of tyrp1
1) Confidence 0.51 Published 2003 Journal Pigment Cell Res. Section Abstract Doc Link 12519127 Disease Relevance 0.51 Pain Relevance 0.29
For example, dose-response curves for His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (SK&F 110679) inhibition of the binding of DAGO and DPDPE yielded IC50's of 6 and 20 microM, respectively.
Negative_regulation (inhibition) of Trp
2) Confidence 0.42 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 2853311 Disease Relevance 0 Pain Relevance 0.72
For example, dose-response curves for His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (SK&F 110679) inhibition of the binding of DAGO and DPDPE yielded IC50's of 6 and 20 microM, respectively.
Negative_regulation (inhibition) of Trp
3) Confidence 0.42 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 2853311 Disease Relevance 0 Pain Relevance 0.72
After removal of the tumor, clinical symptoms disappeared and hypophosphatemia, decreased TRP, and the 1,25-dihydroxyvitamin D level were corrected.
Negative_regulation (decreased) of TRP associated with cancer and hypophosphatemia
4) Confidence 0.42 Published 1996 Journal Pathol. Int. Section Abstract Doc Link 10846577 Disease Relevance 1.02 Pain Relevance 0.08
Thus these results show that removal of Trp from the balanced amino acid mixture decreases spontaneous and d-fenfluramine-induced release of 5-HT in the hippocampus.
Negative_regulation (removal) of Trp in hippocampus associated with hippocampus
5) Confidence 0.37 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9087665 Disease Relevance 0 Pain Relevance 0.21
A recent study using analbuminaemic rats has shown an improvement in exercise performance after reducing brain Trp uptake by blocking the L-system carrier using 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid, a specific inhibitor of the L-system transporter [34].
Negative_regulation (reducing) of Trp in brain
6) Confidence 0.23 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2896923 Disease Relevance 0.16 Pain Relevance 0.07
At this point, four channelopathies have been identified in which a defect in a TRP channel-encoding gene is the direct cause of disease.
Negative_regulation (defect) of TRP associated with trp channel, disease and channelopathies
7) Confidence 0.09 Published 2005 Journal Sci. STKE Section Abstract Doc Link 16077087 Disease Relevance 0.88 Pain Relevance 0.20
The known inhibitor Trp-Pro-Trp binding affinity for the target protein was determined by AutoDock as ?
Negative_regulation (inhibitor) of Trp
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0 Pain Relevance 0
The HIV-1 protease, SPG-40, HLA-B*2705 and Con A proteins have Trp and Tyr residues on their own inhibitory peptides; and proteinase K protein binding surface contains Trp, Phe and His residues on its binding surface.
Negative_regulation (residues) of Trp associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2880006 Disease Relevance 0.10 Pain Relevance 0
The Km(Trp) values for TPH2A and TPH2B were nearly similar (Table 2), but significantly higher for the edited variants, indicating a reduced affinity for the substrate Trp (Table 2).
Negative_regulation (reduced) of Trp
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.05 Pain Relevance 0.14
RNA editing of TPH2b resulted in a 50% decrease of Vmax of the corresponding TPH2B 234 protein, which exhibited the highest Km(Trp) value of all variants (Table 2).
Negative_regulation (exhibited) of Trp
11) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0 Pain Relevance 0.10

General Comments

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