INT300446

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.62
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (VEGFA, Flt1) cell differentiation (Flt1) endosome (Flt1)
Golgi apparatus (Flt1) extracellular space (VEGFA) extracellular region (VEGFA)
Anatomy Link Frequency
liver 2
VEGFA (Homo sapiens)
Flt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 14 66.64 Quite High
cytokine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibromyalgia 4 100.00 Very High Very High Very High
Age-related Macular Degeneration 14 99.72 Very High Very High Very High
Diabetic Macular Edema 42 97.80 Very High Very High Very High
Retinal Diseases 4 97.36 Very High Very High Very High
Edema 2 94.68 High High
Diabetes Mellitus 110 89.36 High High
Cicatrix 2 59.40 Quite High
Blindness 6 57.52 Quite High
Leukostasis 2 46.32 Quite Low
Cataract 6 21.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGF-A activates two tyrosine-kinase receptors, fms-like tyrosine kinase-1 (FLT-1, vascular endothelial growth factor receptor-1), and fetal liver kinase-1 (FLK-1, vascular endothelial growth factor receptor-2) (10), which autophosphorylate to initiate a signaling cascade that results in increased microvascular permeability and angiogenesis (11).
VEGF Positive_regulation (activates) of FLT-1 in liver associated with fibromyalgia
1) Confidence 0.09 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 1.31 Pain Relevance 0.03
VEGF-A activates two tyrosine-kinase receptors, fms-like tyrosine kinase-1 (FLT-1, vascular endothelial growth factor receptor-1), and fetal liver kinase-1 (FLK-1, vascular endothelial growth factor receptor-2) (10), which autophosphorylate to initiate a signaling cascade that results in increased microvascular permeability and angiogenesis (11).
VEGF Positive_regulation (activates) of fms-like tyrosine kinase in liver associated with fibromyalgia
2) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 1.31 Pain Relevance 0.03

General Comments

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