INT300448

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.93
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (VEGFA, Flt1) cell differentiation (Flt1) endosome (Flt1)
Golgi apparatus (Flt1) extracellular space (VEGFA) extracellular region (VEGFA)
Anatomy Link Frequency
endothelial cells 2
VEGFA (Homo sapiens)
Flt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 26.88 Quite Low
agonist 2 20.92 Low Low
Dopamine 2 20.60 Low Low
imagery 12 19.60 Low Low
corticosteroid 14 9.60 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 74 91.84 High High
Diabetes Mellitus 110 89.20 High High
Pituitary Cancer 16 77.28 Quite High
Ganglion Cysts 4 76.96 Quite High
Diabetic Macular Edema 42 64.56 Quite High
Apoptosis 24 63.12 Quite High
Hypoxia 8 51.48 Quite High
Prolactinoma 2 50.00 Quite Low
Death 4 42.04 Quite Low
Injury 4 36.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGF-A binds both VEGFR-1 and VEGFR-2, while PlGF and VEGF-B interact only with VEGFR-1.
VEGF Binding (interact) of VEGFR-1
1) Confidence 0.10 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.37 Pain Relevance 0
VEGF-A binds both VEGFR-1 and VEGFR-2, while PlGF and VEGF-B interact only with VEGFR-1.
VEGF Binding (interact) of VEGFR-1
2) Confidence 0.10 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.31 Pain Relevance 0
Furthermore, VEGF-A mutants that bind selectively to FLK-1 are able to induce mitogenesis and chemotaxis in endothelial cells, and vascular permeability and angiogenesis in vivo, whereas VEGF-A mutants that selectively bind to FLT-1 do not have the activities stated above (29,30).
VEGF Binding (bind) of FLT-1 in endothelial cells
3) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.63 Pain Relevance 0
Furthermore, VEGF-A mutants that bind selectively to FLK-1 are able to induce mitogenesis and chemotaxis in endothelial cells, and vascular permeability and angiogenesis in vivo, whereas VEGF-A mutants that selectively bind to FLT-1 do not have the activities stated above (29,30).
VEGF Binding (bind) of FLT-1 in endothelial cells
4) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.61 Pain Relevance 0

General Comments

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