INT300488

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.03
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP, LEP) extracellular region (CRP, LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
hypothalamus 1
plasma 1
CRP (Homo sapiens)
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 97.88 Very High Very High Very High
Inflammatory marker 3 86.96 High High
Inflammatory response 3 83.52 Quite High
Serotonin 36 75.80 Quite High
headache 3 42.68 Quite Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 30 97.88 Very High Very High Very High
Obesity 27 95.36 Very High Very High Very High
Stress 18 91.52 High High
Metabolic Syndrome 84 88.80 High High
Weight Gain 9 88.32 High High
Pressure And Volume Under Development 9 78.56 Quite High
Heart Disease 6 77.20 Quite High
Body Weight 36 73.72 Quite High
Disorder Of Lipid Metabolism 48 69.56 Quite High
Diabetes Mellitus 12 59.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As discussed earlier, some researchers believe the binding of CRP to leptin may be the reason [16].
CRP Binding (binding) of leptin
1) Confidence 0.46 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.94 Pain Relevance 0.22
In vivo and in vitro research done at the University of Pittsburgh demonstrated that CRP binds to leptin thereby impairing its signaling in two ways: 1) the coupling of CRP to leptin makes crossing the blood-brain barrier nearly impossible, thus preventing "free" leptin access to the hypothalamus; 2) the CRP/leptin complex inhibits the binding of leptin to its receptors, thus blocking its ability to signal in cultured cells.
CRP Binding (binds) of leptin in hypothalamus
2) Confidence 0.46 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.64 Pain Relevance 0.09
Since human CRP correlates with increased plasma leptin and adiposity, the results "suggest a potential mechanism to leptin resistance, by which circulating CRP binds to leptin and attenuates its physiological functions [16].
CRP Binding (binds) of leptin in plasma
3) Confidence 0.34 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.46 Pain Relevance 0.07

General Comments

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