INT300514

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.85
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (VEGFC) signal transduction (VEGFC) extracellular space (VEGFC)
extracellular region (VEGFC)
Anatomy Link Frequency
MCF7 4
fat pads 2
PGE2 2
VEGFC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 69 94.28 High High
metalloproteinase 1 77.12 Quite High
cINOD 63 61.12 Quite High
aspirin 18 37.52 Quite Low
fibrosis 12 6.12 Low Low
alcohol 12 5.56 Low Low
Freund adjuvant 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Buprenorphine 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 247 99.96 Very High Very High Very High
Carcinoma 9 99.64 Very High Very High Very High
Metastasis 33 97.24 Very High Very High Very High
Breast Cancer 20 97.12 Very High Very High Very High
INFLAMMATION 71 94.28 High High
Severe Combined Immunodeficiency 8 92.64 High High
Head & Neck Cancer 6 81.56 Quite High
Recurrence 1 76.96 Quite High
Pathologic Neovascularization 12 68.04 Quite High
Squamous Cell Neoplasms 2 67.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar results were reported with VEGF-C overexpressing MDA-MB-435 [30].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of VEGF-C
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 1.03 Pain Relevance 0.08
We first used a orthotopic graft model of VEGF-C overexpressing-mammary carcinoma cells (MCF7).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of VEGF-C in MCF7 associated with carcinoma
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 1.00 Pain Relevance 0.09
In the present study, MCF7 cells overexpressing or not VEGF-C were inoculated into RAG-1?
Neg (not) Positive_regulation (overexpressing) of Gene_expression (overexpressing) of VEGF-C in MCF7
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.97 Pain Relevance 0.07
To test the impact of PAI-1 on lymphatic vessel recruitment in tumors, VEGF-C-overexpressing MCF7 cells or control MCF7 cells were bilaterally injected into the fifth mammary fat pads (mfp) of immunodeficient RAG-1?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of VEGF-C in fat pads associated with cancer
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2836381 Disease Relevance 0.28 Pain Relevance 0
Increased levels of COX-2 expression and PGE2 have also been shown to induce cell proliferation as well as angiogenesis by increasing the production of vascular-endothelial growth factor by epithelial cells [34].
Positive_regulation (increasing) of Gene_expression (production) of vascular-endothelial growth factor in PGE2
5) Confidence 0.08 Published 2010 Journal International Journal of Otolaryngology Section Body Doc Link PMC2902018 Disease Relevance 0.57 Pain Relevance 0.10

General Comments

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