INT300538

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.98
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17f) extracellular region (Il17f)
Anatomy Link Frequency
memory T cells 1
Il17f (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 1 98.76 Very High Very High Very High
Inflammation 36 98.48 Very High Very High Very High
cytokine 64 97.96 Very High Very High Very High
rheumatoid arthritis 54 96.76 Very High Very High Very High
Crohn's disease 53 84.40 Quite High
Arthritis 86 83.72 Quite High
cINOD 1 25.44 Quite Low
chemokine 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 98.48 Very High Very High Very High
Rheumatoid Arthritis 54 96.76 Very High Very High Very High
Disease 83 84.40 Quite High
Arthritis 69 83.72 Quite High
Inflammatory Bowel Disease 54 74.44 Quite High
Autoimmune Disease 6 63.96 Quite High
Seronegative Spondarthritis 7 56.16 Quite High
Ileal Diseases 5 33.12 Quite Low
Experimental Arthritis 7 30.56 Quite Low
Systemic Sclerosis 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed increase in expression levels of IL17A, IL17F, IL22 and IL26 and the downstream proinflammatory cytokines IL6 and IL1?
Negative_regulation (levels) of IL17F associated with cytokine
1) Confidence 0.26 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.89 Pain Relevance 0.44
Interestingly, 1,25-(OH)2D3, in contrast to dexamethasone, directly modulated human Th17 polarization accompanied with suppression of IL-17A, IL-17F, TNF-alpha, and IL-22 production by FACS sorted memory T cells from these early RA patients [14].


Negative_regulation (suppression) of IL-17F in memory T cells associated with rheumatoid arthritis and dexamethasone
2) Confidence 0.05 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.09 Pain Relevance 0.63

General Comments

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