INT300541

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Context Info
Confidence 0.26
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.60
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il17f) extracellular region (Il17f)
Anatomy Link Frequency
memory T cells 2
Il17f (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 62 98.92 Very High Very High Very High
dexamethasone 1 98.76 Very High Very High Very High
rheumatoid arthritis 54 98.08 Very High Very High Very High
cytokine 109 97.96 Very High Very High Very High
Arthritis 87 86.00 High High
Crohn's disease 53 84.84 Quite High
chemokine 9 82.92 Quite High
cINOD 1 25.44 Quite Low
fibrosis 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 104 99.84 Very High Very High Very High
INFLAMMATION 59 98.92 Very High Very High Very High
Rheumatoid Arthritis 54 98.08 Very High Very High Very High
Adhesions 2 92.00 High High
Arthritis 70 86.00 High High
Disease 97 84.84 Quite High
Inflammatory Bowel Disease 54 74.88 Quite High
Eosinophilia 8 74.40 Quite High
Hyperplasia 4 71.60 Quite High
Hypersensitivity 24 67.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed increase in expression levels of IL17A, IL17F, IL22 and IL26 and the downstream proinflammatory cytokines IL6 and IL1?
Negative_regulation (levels) of Gene_expression (expression) of IL17F associated with cytokine
1) Confidence 0.26 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 0.90 Pain Relevance 0.44
Increased expression of IL-17F has already been detected in asthmatic patients after allergen challenge.
Negative_regulation (detected) of Gene_expression (expression) of IL-17F associated with asthma
2) Confidence 0.06 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.60 Pain Relevance 0.19
Interestingly, 1,25-(OH)2D3, in contrast to dexamethasone, directly modulated human Th17 polarization accompanied with suppression of IL-17A, IL-17F, TNF-alpha, and IL-22 production by FACS sorted memory T cells from these early RA patients [14].


Negative_regulation (suppression) of Gene_expression (production) of IL-17F in memory T cells associated with rheumatoid arthritis and dexamethasone
3) Confidence 0.05 Published 2010 Journal Semin Immunopathol Section Body Doc Link PMC2836464 Disease Relevance 1.11 Pain Relevance 0.64

General Comments

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