INT300588

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.67
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd5) signal transducer activity (Drd5)
Anatomy Link Frequency
neuronal 1
Drd5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dopamine receptor 4 99.92 Very High Very High Very High
long-term potentiation 1 98.84 Very High Very High Very High
Dopamine 2 96.04 Very High Very High Very High
cocaine 105 90.40 High High
addiction 5 87.76 High High
adenocard 3 85.84 High High
GABAergic 3 63.76 Quite High
Neurotransmitter 7 62.96 Quite High
Morphine 2 61.20 Quite High
alcohol 1 60.40 Quite High
Disease Link Frequency Relevance Heat
Injury 66 99.24 Very High Very High Very High
Drug Dependence 2 87.76 High High
Aids-related Complex 11 53.72 Quite High
Spinal Cord Injury 19 5.00 Very Low Very Low Very Low
Spasticity 18 5.00 Very Low Very Low Very Low
Cocaine Dependence 10 5.00 Very Low Very Low Very Low
Recurrence 8 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Repression 3 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The gene coding for dopamine receptor 5 (Drd5, profile 11) is subject to early down-regulation 2 and 7 days post injury, but returns to control levels in the late phase 60 days post injury.
Regulation (regulation) of Drd5 associated with dopamine receptor and injury
1) Confidence 0.32 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.42 Pain Relevance 0.28
Although the mechanisms underlying these effects are unclear, Drd5 signaling is implicated in neuronal activities including long-term potentiation (LTP; [35]), and reinforcement learning [36], while both Drd5 [37] and Adora2b [38] appear to affect Ca2+ dynamics.
Spec (appear) Regulation (affect) of Drd5 in neuronal associated with long-term potentiation
2) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.25 Pain Relevance 0.40

General Comments

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