INT300602

Context Info Confidence 0.38 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.59

plasma membrane (Adora2b) signal transducer activity (Adora2b)

Adora2b (Rattus norvegicus)

Pain Link Frequency Relevance Heat cocaine 210 100.00 adenocard 6 99.98 dopamine receptor 4 95.84 Nucleus accumbens 70 93.92 addiction 10 5.00 Neuropeptide 6 5.00 withdrawal 4 5.00 Morphine 4 5.00 Neurotransmitter 4 5.00 long-term potentiation 2 5.00

Disease Link Frequency Relevance Heat Aids-related Complex 22 14.00 Osteogenic Sarcomas 4 6.56 Cocaine Dependence 20 5.00 Recurrence 16 5.00 Necrosis 4 5.00 Cancer 4 5.00 Drug Dependence 4 5.00 Attention Deficit Hyperactivity Disorder 2 5.00 Disease 2 5.00 Stress 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Finally, levels of adenosine A2B receptor (Adora2b) were unchanged by cocaine administration, but were reduced by 20% after 10-days of abstinence (Category 3 change) (Figure 2D).

Negative_regulation (reduced) of Adora2b associated with adenocard and cocaine

1) Confidence 0.38 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0 Pain Relevance 0.30

Finally, levels of adenosine A2B receptor (Adora2b) were unchanged by cocaine administration, but were reduced by 20% after 10-days of abstinence (Category 3 change) (Figure 2D).

Negative_regulation (reduced) of A2B receptor associated with adenocard and cocaine

2) Confidence 0.33 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0 Pain Relevance 0.30

General Comments

This test has worked.