INT30061

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Context Info
Confidence 0.59
First Reported 1988
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 2.14
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hdc) lyase activity (Hdc) cellular amino acid metabolic process (Hdc)
Hdc (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 9 99.92 Very High Very High Very High
Morphine 25 98.64 Very High Very High Very High
pulpitis 1 98.02 Very High Very High Very High
Nicotine 1 97.04 Very High Very High Very High
Hyperalgesia 1 95.80 Very High Very High Very High
Dopamine 14 93.72 High High
Somatostatin 3 76.16 Quite High
Neurotransmitter 4 72.20 Quite High
Opioid 1 72.04 Quite High
Catecholamine 1 71.56 Quite High
Disease Link Frequency Relevance Heat
Suicidal Behaviour 12 99.98 Very High Very High Very High
Stress 9 99.76 Very High Very High Very High
Targeted Disruption 12 99.24 Very High Very High Very High
Disease 2 99.14 Very High Very High Very High
Periodontitis 1 98.60 Very High Very High Very High
Mouth Disease 1 98.30 Very High Very High Very High
Pulpitis 1 98.02 Very High Very High Very High
Hyperalgesia 1 95.80 Very High Very High Very High
Appetite Loss 8 81.56 Quite High
Pain 4 40.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results also suggest that histamine produced in oral tissues in response to bacterial agents such as LPS could be involved in development of pulpitis or gingivitis (periodontitis), the most common diseases in the dental clinic, and that efforts to inhibit HDC activity, which elevates histamine levels in oral tissues, might offer the basis for novel treatment strategies.
Negative_regulation (inhibit) of HDC associated with periodontitis, pulpitis, mouth disease and disease
1) Confidence 0.59 Published 2006 Journal Arch. Oral Biol. Section Abstract Doc Link 16769033 Disease Relevance 0.39 Pain Relevance 0.10
Therefore, the HA turnover rate is determined by either a exponential decrease in HA level after treatment with alpha-fluoromethylhistidine (alpha-FMH), a specific HDC inhibitor, or a linear accumulation of t-MH after pargyline treatment.
Negative_regulation (inhibitor) of HDC
2) Confidence 0.55 Published 1988 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 2854108 Disease Relevance 0 Pain Relevance 0.07
After cessation of RCS treatment, HDC mRNA level decreased and reached the level of non-RCS treated mice, but HDC activity did not.
Negative_regulation (decreased) of HDC associated with stress
3) Confidence 0.43 Published 1995 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 8750791 Disease Relevance 0.89 Pain Relevance 0.10
-fluoromethylhistidine (a specific suicide inhibitor of histidine decarboxylase) and in mice with targeted disruption of histamine H1 receptors.
Negative_regulation (inhibitor) of histidine decarboxylase associated with targeted disruption and suicidal behaviour
4) Confidence 0.30 Published 2007 Journal Journal of Neurochemistry Section Abstract Doc Link PMC2156111 Disease Relevance 0.20 Pain Relevance 0
On the other hand, the histidine decarboxylase inhibitor, alpha-fluoromethylhistidine (alpha-FMH), significantly potentiated the morphine (1 mg/kg)-induced place preference.
Negative_regulation (inhibitor) of histidine decarboxylase associated with morphine
5) Confidence 0.27 Published 1995 Journal Brain Res. Section Abstract Doc Link 7796129 Disease Relevance 0 Pain Relevance 0.92
The effects of an H2 receptor antagonist, a histidine decarboxylase inhibitor and a histamine precursor on the morphine-induced place preference in mice were examined.
Negative_regulation (inhibitor) of histidine decarboxylase associated with antagonist and morphine
6) Confidence 0.27 Published 1995 Journal Brain Res. Section Abstract Doc Link 7796129 Disease Relevance 0 Pain Relevance 0.65
Cultured BAM cells have histidine decarboxylase activity which is inhibited by alpha-fluoromethylhistidine.
Negative_regulation (inhibited) of histidine decarboxylase
7) Confidence 0.26 Published 1993 Journal Eur. J. Neurosci. Section Abstract Doc Link 7506970 Disease Relevance 0 Pain Relevance 0.16
Leptin-induced suppression of feeding was reported to be attenuated both in rats whose histamine was depleted by FMH, a suicide inhibitor of histamine synthesizing HDC enzyme, and in H1KO mice (Yoshimatsu et al. 1998; Masaki et al. 2001).
Negative_regulation (inhibitor) of HDC enzyme associated with suicidal behaviour
8) Confidence 0.22 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.26 Pain Relevance 0.03
-fluoromethylhistidine (FMH), a suicide inhibitor of histamine synthesizing histidine decarboxylase (HDC) enzyme as well as in mice with targeted disruption of histamine H1 receptors (H1KO mice) (Yoshimatsu et al. 1998; Masaki et al. 2001).
Negative_regulation (inhibitor) of HDC associated with targeted disruption and suicidal behaviour
9) Confidence 0.22 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.20 Pain Relevance 0.04
-fluoromethylhistidine (FMH), a suicide inhibitor of histamine synthesizing histidine decarboxylase (HDC) enzyme as well as in mice with targeted disruption of histamine H1 receptors (H1KO mice) (Yoshimatsu et al. 1998; Masaki et al. 2001).
Negative_regulation (inhibitor) of histidine decarboxylase associated with targeted disruption and suicidal behaviour
10) Confidence 0.19 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2156111 Disease Relevance 0.20 Pain Relevance 0.04
RC-160 suppressed HDC activity after food intake and treatment with omeprazole, NaHCO3, or NaCl.
Negative_regulation (suppressed) of HDC
11) Confidence 0.07 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8638714 Disease Relevance 0 Pain Relevance 0.17

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