INT300623

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 10.65
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (Men1) embryo development (Men1) DNA binding (Men1)
protein complex (Men1) cytoplasm (Men1) cytosol (Men1)
Anatomy Link Frequency
germline 3
Men1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 25 91.40 High High
Serotonin 20 83.08 Quite High
5HT 5 76.40 Quite High
Somatostatin 20 24.92 Low Low
agonist 5 18.28 Low Low
dopamine receptor 5 17.92 Low Low
Dopamine 5 13.60 Low Low
depression 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Endocrine Neoplasia Type 1 390 100.00 Very High Very High Very High
Pheochromocytoma 5 99.92 Very High Very High Very High
Thyroid Neoplasm 5 99.08 Very High Very High Very High
Cancer 200 98.70 Very High Very High Very High
Malignant Neoplastic Disease 20 97.64 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 15 96.80 Very High Very High Very High
Syndrome 35 96.44 Very High Very High Very High
Parathyroid Cancer 40 95.84 Very High Very High Very High
Gastrinoma 25 94.84 High High
Carcinoid 70 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In accordance with Knudson's "two-hit theory", biallelic inactivation of the MEN1 gene is required for the development of a tumour cell [12].
Positive_regulation (inactivation) of MEN1 associated with multiple endocrine neoplasia type 1 and cancer
1) Confidence 0.35 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837063 Disease Relevance 2.30 Pain Relevance 0.22
Also in sporadic MEN1-associated tumours mutations of the MEN1 gene have been found, which suggests that inactivation of the MEN1 gene contributes to the development of these tumours.
Positive_regulation (inactivation) of MEN1 associated with multiple endocrine neoplasia type 1 and cancer
2) Confidence 0.35 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837063 Disease Relevance 2.30 Pain Relevance 0.11
MEN1 is caused by germline mutations of the MEN1 tumour suppressor gene.
Positive_regulation (caused) of MEN1 in germline associated with multiple endocrine neoplasia type 1 and cancer
3) Confidence 0.32 Published 2005 Journal Hered Cancer Clin Pract Section Abstract Doc Link PMC2837063 Disease Relevance 1.59 Pain Relevance 0
MEN1 is caused by germline mutations of the MEN1 gene [1,2].
Positive_regulation (caused) of MEN1 in germline associated with multiple endocrine neoplasia type 1
4) Confidence 0.32 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837063 Disease Relevance 2.15 Pain Relevance 0
MEN1 is caused by inactivating germline mutations of the MEN1 gene, which is located on chromosome 11q13 [1,2].
Positive_regulation (caused) of MEN1 in germline associated with multiple endocrine neoplasia type 1
5) Confidence 0.28 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837063 Disease Relevance 2.31 Pain Relevance 0.24

General Comments

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