INT300717

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.64
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ptrf) endoplasmic reticulum (Ptrf) RNA binding (Ptrf)
rRNA binding (Ptrf) plasma membrane (Ptrf) nucleus (Ptrf)
Anatomy Link Frequency
muscle 1
osteoblasts 1
Ptrf (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 30 95.08 Very High Very High Very High
tolerance 10 32.64 Quite Low
Pain 5 5.00 Very Low Very Low Very Low
abdominal pain 5 5.00 Very Low Very Low Very Low
backache 5 5.00 Very Low Very Low Very Low
potassium channel 5 5.00 Very Low Very Low Very Low
Action potential 5 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lipodystrophy 60 99.96 Very High Very High Very High
Obesity 55 98.44 Very High Very High Very High
Disease 10 93.48 High High
Arrhythmia Under Development 20 92.16 High High
Volume Depletion And Dehydration 15 89.92 High High
Muscle Disease 40 83.36 Quite High
Myocardial Infarction 20 81.12 Quite High
Targeted Disruption 15 79.52 Quite High
Dyslipidemia /

Combined Dyslipidemia

20 76.40 Quite High
Hypertrophic Pyloric Stenosis 35 75.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection of full-length PTRF-CAVIN reestablished the presence of caveolae.
Gene_expression (Transfection) of PTRF-CAVIN
1) Confidence 0.61 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2837386 Disease Relevance 1.16 Pain Relevance 0.04
Prioritizing the 74 genes in this interval with GeneDistiller [15] for an expression in primarily affected tissues (adipocytes, smooth and heart muscle), which was above three times the median intensity, produced PTRF-CAVIN as a single hit.
Gene_expression (produced) of PTRF-CAVIN in muscle associated with obesity
2) Confidence 0.61 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2837386 Disease Relevance 0.75 Pain Relevance 0
The coding region of PTRF-CAVIN with its 5?
Gene_expression (region) of PTRF-CAVIN
3) Confidence 0.53 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2837386 Disease Relevance 0.11 Pain Relevance 0
Homozygous PTRF-CAVIN mutations are pathogenic
Gene_expression (mutations) of PTRF-CAVIN
4) Confidence 0.53 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2837386 Disease Relevance 0.81 Pain Relevance 0
PTRF-CAVIN is expressed in many tissues but highest mRNA-levels are found in adipocytes, muscle (smooth, heart, and skeletal), osteoblasts, but not in neuronal tissue (BioGPS, http://biogps.gnf.org/).
Gene_expression (expressed) of PTRF-CAVIN in osteoblasts associated with obesity
5) Confidence 0.48 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2837386 Disease Relevance 0.74 Pain Relevance 0.14

General Comments

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