INT30074

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Context Info
Confidence 0.50
First Reported 1981
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.99
Pain Relevance 3.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
brain 2
gland 2
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 25 99.98 Very High Very High Very High
withdrawal 5 99.36 Very High Very High Very High
opiate 2 98.72 Very High Very High Very High
Endogenous opioid 2 97.20 Very High Very High Very High
Central nervous system 3 96.08 Very High Very High Very High
Opioid 5 91.48 High High
alcohol 10 90.72 High High
Neuropeptide 1 89.44 High High
Enkephalin 3 87.60 High High
Pain 1 81.04 Quite High
Disease Link Frequency Relevance Heat
Injury 1 95.12 Very High Very High Very High
Body Weight 1 93.12 High High
Congenital Anomalies 1 90.16 High High
Frailty 4 86.04 High High
Pain 1 81.04 Quite High
Nervous System Malformation 1 72.48 Quite High
Poisoning 1 69.44 Quite High
Alcohol Addiction 3 68.68 Quite High
Drug Dependence 2 66.60 Quite High
Drug Induced Neurotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that morphine treatment induced a decrease in the incorporation of the radioactive amino acid into total protein, pro-opiomelanocortin, beta-LPH and beta-endorphin.
Positive_regulation (induced) of Negative_regulation (decrease) of beta-endorphin associated with morphine
1) Confidence 0.50 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6268419 Disease Relevance 0.07 Pain Relevance 0.46
RESULTS: Ovariectomy induced a significant decrease in beta-endorphin and allopregnanolone content in all brain areas analyzed and in circulating levels, whereas it increased allopregnanolone content in the adrenal gland.
Positive_regulation (induced) of Negative_regulation (decrease) of beta-endorphin in brain
2) Confidence 0.50 Published 2007 Journal Menopause Section Body Doc Link 17075429 Disease Relevance 0 Pain Relevance 0
Our results indicate that chronic acamprosate treatment may have beneficial effects, as it increases the beta-endorphin concentration thereby compensating for beta-endorphin deficiency during ethanol withdrawal.
Positive_regulation (compensating) of Negative_regulation (deficiency) of beta-endorphin associated with withdrawal
3) Confidence 0.50 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18162308 Disease Relevance 0.22 Pain Relevance 0.68
Moreover, morphine induced a significant decrease of POMC mRNA in the anterior pituitary gland.
Positive_regulation (induced) of Negative_regulation (decrease) of POMC mRNA in gland associated with morphine
4) Confidence 0.47 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9663647 Disease Relevance 0.22 Pain Relevance 0.92
Here we report that the exposure to a low level of lead induces a decrease of beta-endorphin with a concomitant increase of opiate receptors measured at embryonic day 16 as well as at 7, 15, 40 and 60 days postnatally.
Positive_regulation (induces) of Negative_regulation (decrease) of beta-endorphin associated with opiate
5) Confidence 0.42 Published 1988 Journal Neurotoxicol Teratol Section Abstract Doc Link 2854608 Disease Relevance 0.31 Pain Relevance 0.94
In the present study, dietary administration of the potent antioxidant 21-aminosteroid, U-74389F, completely blocked EV-induced beta-endorphin depletion in the hypothalami of adult female rats.
Positive_regulation (induced) of Negative_regulation (depletion) of beta-endorphin
6) Confidence 0.42 Published 1994 Journal Brain Res. Section Abstract Doc Link 7953715 Disease Relevance 0.10 Pain Relevance 0.13
The results showed that morphine treatment induced a decrease in the incorporation of the radioactive amino acid into total protein, pro-opiomelanocortin, beta-LPH and beta-endorphin.
Positive_regulation (induced) of Negative_regulation (decrease) of pro-opiomelanocortin associated with morphine
7) Confidence 0.41 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6268419 Disease Relevance 0.07 Pain Relevance 0.46

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