INT3008

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Context Info
Confidence 0.58
First Reported 1978
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tail 2
Hyp5 1
Met2 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 9 100.00 Very High Very High Very High
Enkephalin 9 100.00 Very High Very High Very High
Morphine 6 99.54 Very High Very High Very High
narcan 9 99.20 Very High Very High Very High
agonist 3 98.76 Very High Very High Very High
Endogenous opioid 1 98.58 Very High Very High Very High
tail-flick 1 98.42 Very High Very High Very High
Opioid 3 90.08 High High
MU agonist 1 82.64 Quite High
opioid receptor 1 67.64 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DAMGO and DAMGA were full agonist prototypes, morphine, endomorphin-1, endomorphin-1-ol, Dmt-endomorphin-1, endomorphin-2-ol and (D-Met2)-endomorphin-2 were found by both methods to be partial agonists whereas the parameters for normorphine, morphiceptin and endomorphin-2 were intermediate.
Gene_expression (found) of Met2 associated with agonist and morphine
1) Confidence 0.58 Published 2006 Journal Peptides Section Abstract Doc Link 16413634 Disease Relevance 0 Pain Relevance 0.56
When this method was utilized we found that a series of endogenous opioid peptides and enkephalin analogues, (D-Ala2,Met5)-enkephalinamide and (D-Met2,Pro5)-enkephalinamide produced dose-related analgesic effects, as determined by the tail pinch test.
Gene_expression (produced) of D-Met2 in tail associated with analgesic, endogenous opioid and enkephalin
2) Confidence 0.38 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 582583 Disease Relevance 0 Pain Relevance 0.75
The preparation of a beta-galactosylated hydroxyproline derivative and its use in the multi-gram solid-phase synthesis of the potent analgesic neoglycopeptide O1.5-beta-D-galactopyranosyl [D-Met2, Hyp5]enkephalinamide is described in this paper.
Gene_expression (synthesis) of D-Met2 in Hyp5 associated with analgesic
3) Confidence 0.08 Published 1997 Journal J. Pept. Sci. Section Abstract Doc Link 9230475 Disease Relevance 0 Pain Relevance 0.17
The in vivo equivalent of pA2 values were determined in rat tail-flick and mouse hot-plate tests for naloxone against morphine, beta-endorphin and a synthetic enkephalin analog, (D-Met2,Pro5)-enkephalinamide, as analgesics.
Gene_expression (synthetic) of D-Met2 in tail associated with analgesic, narcan, tail-flick, enkephalin and morphine
4) Confidence 0.07 Published 1978 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 731437 Disease Relevance 0 Pain Relevance 1.06

General Comments

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