INT300848

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.29
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) extracellular region (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
stem cells 1
Cxcl12 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 34 98.52 Very High Very High Very High
Inflammation 23 94.72 High High
chemokine 31 91.84 High High
trk B 1 87.92 High High
Inflammatory response 4 85.44 High High
imagery 5 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 35 99.84 Very High Very High Very High
INFLAMMATION 27 94.72 High High
Carcinoma 25 94.16 High High
Breast Cancer 4 93.72 High High
Immunization 47 87.16 High High
Bordatella Infection 3 86.24 High High
Hematological Disease 12 84.32 Quite High
Disease 66 83.80 Quite High
Alzheimer's Dementia 23 82.12 Quite High
Colon Cancer 25 63.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that CXCL12-mediated loss of adhesion requires activation of G?
Negative_regulation (loss) of CXCL12-mediated associated with adhesions
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.21 Pain Relevance 0.11
and SDF1 decreased, implicating a beneficial role for these cytokines in mediating anti-A?
Negative_regulation (decreased) of SDF1 associated with cytokine
2) Confidence 0.32 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2955708 Disease Relevance 0.91 Pain Relevance 0.45
Previous reports have indicated that elevated FGF2 decreased both stromal cell derived factor-1 (SDF-1;CXCL12) mRNA and protein in vivo and also diminished the capacity of BMSC to support the expansion of peripheral blood derived stem cells[53].
Negative_regulation (decreased) of CXCL12 in stem cells
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.17 Pain Relevance 0.12

General Comments

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