INT300851

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.01
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf2) signal transduction (Fgf2) extracellular space (Fgf2)
extracellular region (Fgf2) nucleus (Fgf2) embryo development (Fgf2)
Anatomy Link Frequency
astrocyte 4
stem cells 2
Fgf2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 98 100.00 Very High Very High Very High
Inflammatory response 4 86.00 High High
trk B 1 84.00 Quite High
metalloproteinase 1 75.44 Quite High
cytokine 10 69.48 Quite High
Central nervous system 22 51.52 Quite High
Inflammation 13 40.40 Quite Low
medulla 30 5.00 Very Low Very Low Very Low
Peripheral nervous system 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 39 94.28 High High
Aging 24 89.60 High High
INFLAMMATION 17 85.60 High High
Apoptosis 23 84.88 Quite High
Hematological Disease 12 84.88 Quite High
Spinal Cord Injury 24 62.88 Quite High
Targeted Disruption 6 34.88 Quite Low
Injury 25 30.20 Quite Low
Adhesions 7 5.00 Very Low Very Low Very Low
Amputation 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, an increase in FGF-2 mRNA in the spinal cord precedes the observed increase in FGF-2 immunoreactivity (Moftah et al., 2008) suggesting that it might be responsible, at least in part, for the increase in astrocyte immunoreactivity marked by GFAP.
Negative_regulation (precedes) of Positive_regulation (increase) of FGF-2 in astrocyte associated with spinal cord
1) Confidence 0.42 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.12 Pain Relevance 0.14
Similarly, an increase in FGF-2 mRNA in the spinal cord precedes the observed increase in FGF-2 immunoreactivity (Moftah et al., 2008) suggesting that it might be responsible, at least in part, for the increase in astrocyte immunoreactivity marked by GFAP.
Negative_regulation (precedes) of Positive_regulation (increase) of FGF-2 mRNA in astrocyte associated with spinal cord
2) Confidence 0.42 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2990542 Disease Relevance 0.12 Pain Relevance 0.11
In conclusion, our work demonstrates that radiation inhibits VEGF and FGF-2–induced angiogenesis through TGF-?
Negative_regulation (inhibits) of Positive_regulation (induced) of FGF-2
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.60 Pain Relevance 0.04
Previous reports have indicated that elevated FGF2 decreased both stromal cell derived factor-1 (SDF-1;CXCL12) mRNA and protein in vivo and also diminished the capacity of BMSC to support the expansion of peripheral blood derived stem cells[53].
Negative_regulation (decreased) of Positive_regulation (elevated) of FGF2 in stem cells
4) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.17 Pain Relevance 0.12

General Comments

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