INT300863

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.11
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Bdnf (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 8 45.08 Quite Low
Inflammation 13 44.68 Quite Low
Calcitonin gene-related peptide 1 18.40 Low Low
Inflammatory response 4 11.68 Low Low
Arthritis 3 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
trk B 1 5.00 Very Low Very Low Very Low
qutenza 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 59.76 Quite High
Lung Injury 1 50.52 Quite High
Burns 1 49.72 Quite Low
INFLAMMATION 17 44.68 Quite Low
Hematological Disease 12 40.40 Quite Low
Malignant Neoplastic Disease 2 39.84 Quite Low
Infection 3 5.84 Low Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggest ERK and p38 MAPK pathways are required for optimal BMSC IL-6 induction by NGF and BDNF, with these pathways likely involved in baseline expression of IL-6 as a reduction in steady state expression was noted with both inhibitors in the absence of any neurotrophic stimulation.
BDNF Positive_regulation (required) of ERK
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.11 Pain Relevance 0

General Comments

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