INT300864

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.38
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) extracellular space (Ngf)
Anatomy Link Frequency
neurons 1
Ngf (Mus musculus)
Mapk14 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 45 100.00 Very High Very High Very High
allodynia 39 99.92 Very High Very High Very High
Pain 17 87.72 High High
Spinal cord 6 87.08 High High
Cold hyperalgesia 1 79.52 Quite High
IPN 2 68.76 Quite High
Trk A 12 68.16 Quite High
Peripheral nervous system 1 65.08 Quite High
central pain 1 63.12 Quite High
Neuropathic pain 4 61.36 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 48 99.92 Very High Very High Very High
Pain 15 87.72 High High
Diabetes Mellitus 44 79.40 Quite High
Hyperalgesia 7 79.12 Quite High
Nervous System Injury 3 69.84 Quite High
Inflammatory Pain 2 68.76 Quite High
Syndrome 1 63.52 Quite High
Targeted Disruption 5 59.44 Quite High
Osteoarthritis 1 52.24 Quite High
INFLAMMATION 40 50.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NGF activates p38 in primary DRG neurons [10,30].
NGF Positive_regulation (activates) of p38 in neurons associated with nerve growth factor
1) Confidence 0.60 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 1.27 Pain Relevance 1.32
Our data suggest ERK and p38 MAPK pathways are required for optimal BMSC IL-6 induction by NGF and BDNF, with these pathways likely involved in baseline expression of IL-6 as a reduction in steady state expression was noted with both inhibitors in the absence of any neurotrophic stimulation.
NGF Positive_regulation (required) of p38
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.11 Pain Relevance 0

General Comments

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