INT300867

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.42
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) extracellular space (Il6)
Mapk1 (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 8 58.48 Quite High
Inflammation 13 58.08 Quite High
Calcitonin gene-related peptide 1 31.80 Quite Low
Inflammatory response 4 25.08 Quite Low
Arthritis 3 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
trk B 1 5.00 Very Low Very Low Very Low
qutenza 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 73.16 Quite High
Lung Injury 1 63.92 Quite High
Burns 1 63.12 Quite High
INFLAMMATION 17 58.08 Quite High
Hematological Disease 12 53.80 Quite High
Malignant Neoplastic Disease 2 53.24 Quite High
Apoptosis 5 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we observe that ERK1/2 and p38 MAPK pharmacological inhibitors (U0126 and SB203580) significantly reduced IL-6 production by BMSC during exposure to NGF or BDNF (Figure 7).
Negative_regulation (inhibitors) of ERK1/2 Negative_regulation (reduced) of Gene_expression (production) of IL-6
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.42 Pain Relevance 0.08

General Comments

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