INT300870

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf, Il6) extracellular space (Il6) cytoplasmic membrane-bounded vesicle (Bdnf)
Bdnf (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 16 97.44 Very High Very High Very High
Inflammation 26 50.00 Quite Low
qutenza 2 18.44 Low Low
Arthritis 6 7.80 Low Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
trk B 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 34 50.00 Quite Low
Targeted Disruption 8 43.72 Quite Low
Hematological Disease 24 36.64 Quite Low
Lung Injury 2 34.48 Quite Low
Burns 2 33.68 Quite Low
Infection 6 33.52 Quite Low
Malignant Neoplastic Disease 4 23.80 Low Low
Neurodegenerative Disease 4 10.80 Low Low
Asthma 4 9.56 Low Low
Arthritis 4 7.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure to NGF or BDNF increases IL-6 gene expression in the BMSC
BDNF Positive_regulation (increases) of Gene_expression (expression) of IL-6 gene
1) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0 Pain Relevance 0.05
The inhibition noted following stimulation was approximately 50% suggesting that other pathways are also involved in NGF and BDNF stimulated IL-6 production.
BDNF Positive_regulation (stimulated) of Gene_expression (production) of IL-6
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0 Pain Relevance 0

General Comments

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