INT300872

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf, Il6) extracellular space (Il6) cytoplasmic membrane-bounded vesicle (Bdnf)
Bdnf (Mus musculus)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 8 91.20 High High
trk B 2 78.40 Quite High
cytokine 16 74.68 Quite High
Inflammation 26 42.44 Quite Low
Calcitonin gene-related peptide 2 16.16 Low Low
Arthritis 6 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 34 90.80 High High
Hematological Disease 24 90.08 High High
Targeted Disruption 8 57.52 Quite High
Apoptosis 10 48.76 Quite Low
Lung Injury 2 48.28 Quite Low
Burns 2 47.48 Quite Low
Malignant Neoplastic Disease 4 37.60 Quite Low
Infection 6 5.84 Low Low
Disease 6 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggest ERK and p38 MAPK pathways are required for optimal BMSC IL-6 induction by NGF and BDNF, with these pathways likely involved in baseline expression of IL-6 as a reduction in steady state expression was noted with both inhibitors in the absence of any neurotrophic stimulation.
BDNF Positive_regulation (induction) of IL-6
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.06 Pain Relevance 0
In addition to IL-6, FGF2 was increased more than three-fold that of matched controls by both BDNF and NGF.
BDNF Positive_regulation (increased) of IL-6
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.18 Pain Relevance 0.12

General Comments

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