INT30092

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Context Info
Confidence 0.25
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.33
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Spna1) molecular_function (Spna1) cytoplasm (Spna1)
Anatomy Link Frequency
T cells 2
Spna1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 3 99.40 Very High Very High Very High
tetrodotoxin 1 98.16 Very High Very High Very High
Opioid 3 92.16 High High
agonist 5 90.88 High High
Enkephalin 4 79.08 Quite High
antagonist 2 72.04 Quite High
cytokine 6 57.76 Quite High
Delta opioid receptors 1 51.04 Quite High
tolerance 15 50.00 Quite Low
long-term potentiation 2 16.24 Low Low
Disease Link Frequency Relevance Heat
Lymphopenia 18 95.40 Very High Very High Very High
Disease 87 94.20 High High
Neurodegenerative Disease 12 89.68 High High
Cognitive Disorder 39 89.00 High High
Targeted Disruption 19 86.08 High High
Diabetes Mellitus 14 65.60 Quite High
Alzheimer's Dementia 7 18.24 Low Low
Pain 6 15.20 Low Low
Autoimmune Disease 16 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased HA level was decreased by anti-HA antibody, which indicates that anti-HA antibody actually decreases the HA level.
Negative_regulation (decreased) of Positive_regulation (increased) of HA
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.02 Pain Relevance 0
The enhancement of HA release induced by DAGO (10(-6) M) was blocked completely by naloxone (10(-6) M) but not by tetrodotoxin (10(-6) M).
Negative_regulation (blocked) of Positive_regulation (enhancement) of HA associated with tetrodotoxin and narcan
2) Confidence 0.18 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2855235 Disease Relevance 0 Pain Relevance 0.81
In this HA antigen-independent environment, anti-CD40L again reduced the numbers of highly proliferating CD4+ T cells (Fig. 2A), whereas proliferation profiles of donor CD8+ T cells were not significantly different (Fig. 2B).
Negative_regulation (reduced) of Neg (independent) Positive_regulation (environment) of HA in T cells
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.31 Pain Relevance 0.03

General Comments

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