INT300926

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Context Info
Confidence 0.65
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 6.97
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (OBFC1) nucleus (OBFC1) DNA binding (OBFC1)
Anatomy Link Frequency
lateral 4
AAF 3
brain 1
OBFC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 8 96.72 Very High Very High Very High
Hippocampus 16 96.64 Very High Very High Very High
Glutamate 28 92.96 High High
positron emission tomography 155 87.12 High High
agonist 37 78.20 Quite High
imagery 90 77.40 Quite High
drug abuse 32 72.88 Quite High
gABA 5 63.88 Quite High
Serotonin 24 50.00 Quite Low
Glutamate receptor 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Aggression 544 98.74 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 120 98.20 Very High Very High Very High
Intellectual Impairment 72 97.88 Very High Very High Very High
Infection 60 94.44 High High
Adhesions 16 94.04 High High
Diarrhoea 164 93.52 High High
Sprains And Strains 172 92.48 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 32 84.56 Quite High
Targeted Disruption 3 84.56 Quite High
Impulse Control Disorders 8 82.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, L-AP4 depresses STN-evoked EPSCs in the SNr (Wittmann et al., 2001; 2002;), and inhibits EPSPs in dopaminergic neurones of the SNc (Wigmore and Lacey, 1998), most likely reflecting inhibition of glutamate release from STN terminals in these regions.
Gene_expression (depresses) of STN associated with glutamate
1) Confidence 0.65 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989582 Disease Relevance 0.16 Pain Relevance 0.18
As a primary auditory field, AAF expresses a tonotopic gradient (Figs. 4A, S3A, S3B).
Gene_expression (expresses) of AAF
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906504 Disease Relevance 0 Pain Relevance 0
We found no differences in aggressive behavior, mood state, social status and neuropsychological measures of working memory, emotional intelligence and impulsivity between the C-LHPA and LPA groups, yet the C-LHPA group demonstrated markedly lower 5-HT synthesis in the bilateral OBFC in adulthood relative to those with a normal aggression trajectory.
Gene_expression (synthesis) of OBFC associated with intellectual impairment, aggression and attention deficit hyperactivity disorder
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 1.01 Pain Relevance 0
We recently reported that polymorphic variants in the TPH2 gene (rs4641527; rs2129575; rs1023990; rs6582071), responsible for human brain synthesis, predicted subtle variations in 5-HT synthesis in the OBFC in a mixed sample of healthy volunteers and patients [57].
Gene_expression (synthesis) of OBFC in brain
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.27 Pain Relevance 0.25
22.61, P<0.001; partial eta squared:0.485) and right lateral OBFC (F(1,24)?
Gene_expression (right) of OBFC in lateral
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.36 Pain Relevance 0.15
Lower 5-HT function in the OBFC is perhaps the most widely reported in the literature; hence, our selection of the OBFC as primary VOI in the current study.
Gene_expression (selection) of OBFC
6) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.15 Pain Relevance 0.21
Lower 5-HT function in the OBFC is perhaps the most widely reported in the literature; hence, our selection of the OBFC as primary VOI in the current study.
Gene_expression (selection) of OBFC
7) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.15 Pain Relevance 0.21
0.01; partial eta squared: 0.66), and univariate statistics showing lower normalized K* in the left lateral OBFC (F(1,23)?
Gene_expression (left) of OBFC in lateral
8) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.99 Pain Relevance 0.03
22.61, P<0.001; partial eta squared:0.485) and right lateral OBFC (F(1,24)?
Gene_expression (22.61) of OBFC in lateral
9) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.42 Pain Relevance 0.15
0.001; partial eta squared: 0.41) and in the right lateral OBFC (F(1,23)?
Gene_expression (right) of OBFC in lateral
10) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2889822 Disease Relevance 0.98 Pain Relevance 0.04
Local topographies in convergent inputs create distinct conditions for functional processing and it is, thus, not surprising to see topographic principles expressed by essentially all considered functional aspects in AAF.
Gene_expression (expressed) of AAF
11) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2906504 Disease Relevance 0 Pain Relevance 0
Although three fimbriae encoded by the pAA plasmid are aggA (AAF/I), aafA (AAF/II), and agg-3 (AAF/III), each EAEC isolate carries only one AAF subtype. aggA is responsible for the aggregative phenotype and human erythrocyte haemagglutination of EAEC [63]. aafA allows EAEC to adhere to the intestinal mucosa [64]. agg-3 functions as an adhesin [65].
Gene_expression (/) of aafA in AAF
12) Confidence 0.06 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2837894 Disease Relevance 0.46 Pain Relevance 0
Undoubtedly, other potential AAF and adherence factors exist, and need to be explored.
Gene_expression (explored) of AAF
13) Confidence 0.05 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2837894 Disease Relevance 0.74 Pain Relevance 0
Candidates under investigation as potential critical antigens include the AAF fimbriae and the dispersin protein coat, which might be a promising EAEC immunogen.
Gene_expression (fimbriae) of AAF in fimbriae
14) Confidence 0.05 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2837894 Disease Relevance 0.81 Pain Relevance 0
Although three fimbriae encoded by the pAA plasmid are aggA (AAF/I), aafA (AAF/II), and agg-3 (AAF/III), each EAEC isolate carries only one AAF subtype. aggA is responsible for the aggregative phenotype and human erythrocyte haemagglutination of EAEC [63]. aafA allows EAEC to adhere to the intestinal mucosa [64]. agg-3 functions as an adhesin [65].
Gene_expression (/) of AAF in AAF
15) Confidence 0.05 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2837894 Disease Relevance 0.46 Pain Relevance 0

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