INT30101

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Context Info
Confidence 0.45
First Reported 1985
Last Reported 2011
Negated 2
Speculated 1
Reported most in Abstract
Documents 25
Total Number 28
Disease Relevance 14.38
Pain Relevance 12.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna1a) DNA binding (Cacna1a) transmembrane transport (Cacna1a)
cytoplasm (Cacna1a) cell death (Cacna1a) nucleus (Cacna1a)
Anatomy Link Frequency
paw 3
brain 2
head 1
veins 1
Cacna1a (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 504 100.00 Very High Very High Very High
qutenza 316 100.00 Very High Very High Very High
Migraine 52 100.00 Very High Very High Very High
Opioid 37 100.00 Very High Very High Very High
agonist 24 100.00 Very High Very High Very High
long-term potentiation 296 99.96 Very High Very High Very High
Antinociceptive 12 99.96 Very High Very High Very High
antagonist 89 99.44 Very High Very High Very High
anesthesia 36 99.40 Very High Very High Very High
Calcium channel 9 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Migraine With Aura 48 100.00 Very High Very High Very High
Spinocerebellar Ataxia Type 2 9 100.00 Very High Very High Very High
Ataxia 8 100.00 Very High Very High Very High
Hemiplegia 2 99.92 Very High Very High Very High
Targeted Disruption 28 99.48 Very High Very High Very High
INFLAMMATION 231 98.96 Very High Very High Very High
Increased Venous Pressure Under Development 1 98.80 Very High Very High Very High
Depression 36 98.68 Very High Very High Very High
Pressure And Volume Under Development 101 98.40 Very High Very High Very High
Sleep Disorders 1 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of FHM1 mutations on cortical spreading depression, the phenomenon underlying migraine aura, and on cortical excitatory and inhibitory synaptic transmission in FHM1 knockin mice are also described, and their implications for the disease mechanism discussed.
Regulation (effects) of FHM1 associated with epilepsy, depression, migraine and disease
1) Confidence 0.45 Published 2010 Journal Pflugers Arch. Section Abstract Doc Link 20204399 Disease Relevance 1.35 Pain Relevance 0.23
We further discuss the roles of CACNA1A, ATP1A2, and SCN1A in the pathophysiology of cortical spreading depression, which is the likely correlate of migraine aura.
Regulation (roles) of CACNA1A associated with epilepsy, depression and migraine
2) Confidence 0.44 Published 2006 Journal Nervenarzt Section Abstract Doc Link 16915377 Disease Relevance 1.02 Pain Relevance 0.72
Effects of 5-HT and alpha 1 adrenoceptor antagonists on kappa opioid-induced sedation.
Regulation (Effects) of alpha 1 associated with antagonist, sleep disorders and opioid
3) Confidence 0.42 Published 1988 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 2855271 Disease Relevance 0.10 Pain Relevance 0.56
BACKGROUND: Different mutations in the alpha 1A-subunit of the brain P/Q-type calcium channel gene (CACNA1A) are responsible for familial hemiplegic migraine (FHM), episodic ataxia type 2, and spinocerebellar ataxia type 6 (SCA6).
Regulation (responsible) of SCA6 in brain associated with ataxia, migraine with aura, migraine, calcium channel and spinocerebellar ataxia type 2
4) Confidence 0.38 Published 2003 Journal Arch. Neurol. Section Abstract Doc Link 12707077 Disease Relevance 0.65 Pain Relevance 0.42
CACNA1A (FHM1) gene, the ATP1A2 (FHM2) and the SCN1A (FHM3) are reported for their correlation to FHM.
Regulation (reported) of CACNA1A associated with migraine
5) Confidence 0.34 Published 2009 Journal J. Neurol. Sci. Section Abstract Doc Link 19007941 Disease Relevance 0.65 Pain Relevance 0.55
CACNA1A (FHM1) gene, the ATP1A2 (FHM2) and the SCN1A (FHM3) are reported for their correlation to FHM.
Regulation (reported) of FHM1 associated with migraine
6) Confidence 0.34 Published 2009 Journal J. Neurol. Sci. Section Abstract Doc Link 19007941 Disease Relevance 0.64 Pain Relevance 0.54
Real-time polymerase chain reaction revealed altered expression levels of Cacna1g, Calb2 and Th in Wobbly cerebella, but Cacna1a messenger RNA and protein levels were unchanged.
Neg (unchanged) Regulation (unchanged) of Cacna1a
7) Confidence 0.27 Published 2007 Journal Genes Brain Behav. Section Abstract Doc Link 17376154 Disease Relevance 0.58 Pain Relevance 0.11
Modulation of alpha 1-and alpha 2-adrenoceptor binding sites in the brain of audiogenic seizure susceptible mice (DBA/2J).
Regulation (Modulation) of alpha 1 in brain associated with convulsion
8) Confidence 0.23 Published 1985 Journal Eur. J. Pharmacol. Section Title Doc Link 3002812 Disease Relevance 0.51 Pain Relevance 0.21
A total of 147 affected FHM patients from 44 families were identified.
Regulation (affected) of FHM associated with migraine
9) Confidence 0.23 Published 2002 Journal Brain Section Abstract Doc Link 12023326 Disease Relevance 2.08 Pain Relevance 1.33
In contrast, 3D measurement of the reward mountain readily distinguishes changes in sensitivity, which reflect changes in the value of Fhm, from changes in willingness to pay, which reflects changes in the value of Pe.
Regulation (changes) of Fhm
10) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994896 Disease Relevance 0 Pain Relevance 0.05
Affected from some FHM-1 families experience severe hemiplegic attacks, cerebral oedema and life threatening coma due to minor head trauma.
Regulation (Affected) of FHM-1 in head associated with pressure and volume under development, head trauma and coma
11) Confidence 0.11 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2861067 Disease Relevance 1.50 Pain Relevance 0.19
Selective in vivo targeting of La favors two major applications of this technology in cancer diagnosis and treatment.
Regulation (targeting) of La associated with cancer
12) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 0.85 Pain Relevance 0
In contrast, the alpha 1-adrenoceptor agonist phenylephrine (0.05-50 nmol/kg) did not affect the insulin secretory response to either glucose or carbachol.
Neg (not) Regulation (affect) of alpha 1 associated with agonist
13) Confidence 0.08 Published 1986 Journal Pancreas Section Abstract Doc Link 2882501 Disease Relevance 0 Pain Relevance 0.32
Differential contributions of alpha-1 and alpha-2 adrenoceptors to vasoconstriction in mesenteric arteries and veins of normal and hypertensive mice.
Regulation (contributions) of alpha-1 in veins associated with hypertension and increased venous pressure under development
14) Confidence 0.06 Published 2007 Journal Vascul. Pharmacol. Section Title Doc Link 17329171 Disease Relevance 0.34 Pain Relevance 0.23
L-NAME per se reduced the amplitude of field potentials after HFS, implicating a role of NO in LA-LTP, as demonstrated previously in coronal slices [44].
Regulation (role) of LA associated with long-term potentiation and amygdala
15) Confidence 0.04 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.18
Based on that, we investigated whether changes in NO production are responsible for the suppressive effects of capsaicin on LA-LTP.
Spec (whether) Regulation (responsible) of LA associated with qutenza, long-term potentiation and amygdala
16) Confidence 0.04 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.39
However, co-application of AM251 and capsaicin reduced the inhibitory effect of capsaicin on the magnitude of LA-LTP (AM251: 108.8±4.3% [n?
Regulation (effect) of LA associated with qutenza, long-term potentiation and amygdala
17) Confidence 0.04 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.15
The lG and lA alleles were then resolved on a 2% agarose gel.
Regulation (resolved) of lA
18) Confidence 0.03 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2905344 Disease Relevance 0.12 Pain Relevance 0
After ether anesthesia, capsaicin had a suppressive effect on LA-LTP both in patch clamp and in extracellular recordings.
Regulation (effect) of LA associated with anesthesia, qutenza, long-term potentiation and amygdala
19) Confidence 0.03 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.58
The effects observed with the two higher LA doses were similar to that of indomethacin (10 ?
Regulation (effects) of LA
20) Confidence 0.02 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 0.24 Pain Relevance 0.03

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