INT301044

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.17
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Csn2, Trpm1) extracellular region (Csn2) plasma membrane (Trpm1)
molecular_function (Trpm1) cellular_component (Trpm1) transmembrane transport (Trpm1)
Csn2 (Mus musculus)
Trpm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 12 59.20 Quite High
member 8 16 49.04 Quite Low
ketamine 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Night Blindness 176 100.00 Very High Very High Very High
Myopia 32 82.04 Quite High
Congenital Anomalies 16 81.32 Quite High
Refractive Errors 8 69.60 Quite High
Skin Cancer 4 67.80 Quite High
Astigmatism 4 65.12 Quite High
Ocular Toxicity (including Many Sub-types) 8 60.08 Quite High
Strabismus 4 58.96 Quite High
Pallor 4 37.92 Quite Low
Amblyopia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely that one of the three genes that is localized at the dendritic terminals of ON BCs and contributing the cell activity, TRPM1, GRM6, or NYX, would responsible for most patients with complete CSNB.
CSNB Binding (responsible) of TRPM1 associated with night blindness
1) Confidence 0.09 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0.51 Pain Relevance 0
Clinical characteristics of the complete CSNB patients associated with TRPM1 mutations
CSNB Binding (associated) of TRPM1 associated with night blindness
2) Confidence 0.08 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0.68 Pain Relevance 0
Human TRPM1 mutations are associated with the complete form of CSNB in Japanese patients, suggesting that TRPM1 plays an essential role in mediating the photoresponse in ON BCs in humans as well as in mice.



CSNB Binding (associated) of TRPM1 associated with night blindness
3) Confidence 0.08 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2838739 Disease Relevance 0.50 Pain Relevance 0.03
Very recently three groups reported the association of TRPM1 mutations with CSNB [20-22].
CSNB Binding (association) of TRPM1 associated with night blindness
4) Confidence 0.08 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838739 Disease Relevance 0.48 Pain Relevance 0

General Comments

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