INT301115

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.04
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp2) extracellular space (Mmp2) extracellular region (Mmp2)
proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2) nucleus (Mmp2)
Anatomy Link Frequency
fibroblast 2
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 3 60.44 Quite High
metalloproteinase 5 59.68 Quite High
Inflammation 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 217 99.54 Very High Very High Very High
Metastasis 89 97.32 Very High Very High Very High
Death 5 91.60 High High
Chronic Hepatitis 1 80.40 Quite High
Stress 5 79.68 Quite High
Osteogenic Sarcomas 17 75.00 Quite High
Head & Neck Cancer 6 75.00 Quite High
Hepatitis 1 71.64 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 57.52 Quite High
Solid Tumor 2 45.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of tumor-bearing mice with TGZ decreases the expression and activity of MMP-2 within the tumor, and inhibits primary tumor growth and pulmonary metastasis development.
Negative_regulation (decreases) of Positive_regulation (activity) of MMP-2 associated with cancer and metastasis
1) Confidence 0.38 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2838820 Disease Relevance 1.19 Pain Relevance 0.03
TM treatment significantly decreased tumor cell motility and invasiveness by inhibiting lysyl oxidase (LOX) activity, FAK activation and MMP2 levels.
Negative_regulation (inhibiting) of Positive_regulation (activation) of MMP2 associated with cancer
2) Confidence 0.28 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2922193 Disease Relevance 1.56 Pain Relevance 0.03
Recently, Ryu et al. (2009) demonstrated that methanol extracts of alga Corallina pilulifera possessed a high phenolic content, which reduced the expression of UV-induced MMP-2 and -9, in human dermal fibroblast in a dose dependent manner, thereby attaining the capability of inhibiting free radicals [30].
Negative_regulation (reduced) of Positive_regulation (induced) of MMP-2 in fibroblast
3) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2993000 Disease Relevance 0.29 Pain Relevance 0

General Comments

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