INT301122

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.78
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Akt1) aging (Akt1) enzyme binding (Akt1)
carbohydrate metabolic process (Akt1) cytoplasm (Akt1) cytosol (Akt1)
Anatomy Link Frequency
ES-2 1
Tgm7 (Mus musculus)
Akt1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 10 83.40 Quite High
alcohol 5 60.40 Quite High
antagonist 10 30.92 Quite Low
anesthesia 10 5.00 Very Low Very Low Very Low
Potency 10 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 430 98.88 Very High Very High Very High
Reprotox - General 1 10 98.52 Very High Very High Very High
Metastasis 195 91.68 High High
Osteogenic Sarcomas 85 75.00 Quite High
Bladder Cancer 5 71.28 Quite High
Acidosis 10 58.00 Quite High
Weight Loss 5 41.12 Quite Low
Body Weight 30 26.24 Quite Low
Colon Cancer 5 25.88 Quite Low
Apoptosis 15 24.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, the present findings suggest that inhibition of Akt signaling by TGZ may decrease MMP-2 secretion, thus resulting in the decrease of the invasiveness and motility in LM8 cells.
TGZ Negative_regulation (inhibition) of Akt
1) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.54 Pain Relevance 0
Yang et al. [32] reported that TGZ decreases the level of p-Akt and inhibits cell motility in human ovarian carcinoma cell line, ES-2.
TGZ Negative_regulation (decreases) of p-Akt in ES-2 associated with reprotox - general 1
2) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.49 Pain Relevance 0
TGZ decreased the level of p-Akt in a dose-dependent manner (Figure 4A).
TGZ Negative_regulation (decreased) of p-Akt
3) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.20 Pain Relevance 0.03
TGZ decreased the level of p-Akt.
TGZ Negative_regulation (decreased) of p-Akt
4) Confidence 0.29 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2838820 Disease Relevance 1.12 Pain Relevance 0.04
Since TGZ decreased the level of p-Akt (Figure 4A and 4B), this indicates that TGZ inhibits Akt signaling in LM8 cells.
TGZ Negative_regulation (decreased) of p-Akt
5) Confidence 0.29 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.43 Pain Relevance 0

General Comments

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