INT301129

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.55
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Akt1, Mmp2) plasma membrane (Akt1, Mmp2) cytoplasm (Akt1, Mmp2)
transport (Akt1) aging (Akt1) peptidase activity (Mmp2)
Tgm7 (Mus musculus)
Akt1 (Mus musculus)
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 16.28 Low Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 2 88.80 High High
Metastasis 39 86.08 High High
Cancer 86 70.08 Quite High
Bladder Cancer 1 56.64 Quite High
Osteogenic Sarcomas 17 50.00 Quite Low
Acidosis 2 43.36 Quite Low
Body Weight 6 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Weight Loss 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, the present findings suggest that inhibition of Akt signaling by TGZ may decrease MMP-2 secretion, thus resulting in the decrease of the invasiveness and motility in LM8 cells.
TGZ Negative_regulation (inhibition) of Akt Spec (may) Negative_regulation (decrease) of Localization (secretion) of MMP-2
1) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.55 Pain Relevance 0

General Comments

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