INT301166

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.93
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (LRP2) endosome (LRP2) small molecule metabolic process (LRP2)
Golgi apparatus (LRP2) endoplasmic reticulum (LRP2) plasma membrane (LRP2)
Anatomy Link Frequency
white matter 1
LRP2 (Homo sapiens)
TRD@ (Homo sapiens)
Pain Link Frequency Relevance Heat
deep brain stimulation 124 100.00 Very High Very High Very High
depression 116 100.00 Very High Very High Very High
Nucleus accumbens 12 94.20 High High
Anterior cingulate 4 88.24 High High
Thalamus 14 86.72 High High
imagery 30 64.36 Quite High
insula 2 51.92 Quite High
Pain 2 44.84 Quite Low
antidepressant 4 14.08 Low Low
positron emission tomography 20 6.32 Low Low
Disease Link Frequency Relevance Heat
Depression 118 100.00 Very High Very High Very High
Anxiety Disorder 84 100.00 Very High Very High Very High
Movement Disorders 20 98.32 Very High Very High Very High
Obsessive-compulsive Disorder 18 92.16 High High
Urological Neuroanatomy 6 87.44 High High
Loss Of Sense Of Smell 2 70.48 Quite High
Attention Deficit Hyperactivity Disorder 4 64.56 Quite High
Psychosis 2 52.20 Quite High
Suicidal Behaviour 2 51.64 Quite High
Pain 2 44.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on current technology and understanding of psychiatric circuitry, there seems to be two main areas where DBS can affect TRD: the cingulate white matter and the AL/IC.
DBS Regulation (affect) of TRD in white matter associated with depression and deep brain stimulation
1) Confidence 0.12 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2838907 Disease Relevance 0.77 Pain Relevance 0.59
The first observation of the effects of DBS on OCD and TRD came in the course of using DBS to treat movement disorders.
DBS Regulation (effects) of TRD associated with movement disorders, depression, deep brain stimulation and anxiety disorder
2) Confidence 0.09 Published 2010 Journal BMC Res Notes Section Abstract Doc Link PMC2838907 Disease Relevance 1.16 Pain Relevance 0.62

General Comments

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