INT30117

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Context Info
Confidence 0.71
First Reported 1988
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 25
Disease Relevance 17.45
Pain Relevance 13.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Calm1) nucleoplasm (Calm1) cytoskeleton (Calm1)
cell cycle (Calm1) cellular_component (Calm1) biological_process (Calm1)
Anatomy Link Frequency
hip 1
sciatic nerve 1
cartilage 1
striatum 1
immune system 1
Calm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
complementary and alternative medicine 1581 100.00 Very High Very High Very High
depression 8 99.96 Very High Very High Very High
Arthritis 693 99.78 Very High Very High Very High
Multiple sclerosis 1319 99.54 Very High Very High Very High
fortral 1 99.36 Very High Very High Very High
Osteoarthritis 145 99.32 Very High Very High Very High
antagonist 14 98.36 Very High Very High Very High
opiate 3 97.88 Very High Very High Very High
Inflammation 202 97.28 Very High Very High Very High
chemokine 68 96.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 22 99.96 Very High Very High Very High
Arthritis 473 99.78 Very High Very High Very High
Autoimmune Disease 151 99.64 Very High Very High Very High
Demyelinating Disease 1354 99.54 Very High Very High Very High
Osteoarthritis 142 99.32 Very High Very High Very High
Status Epilepticus 57 98.56 Very High Very High Very High
Rheumatic Diseases 1 98.32 Very High Very High Very High
Disease 567 98.24 Very High Very High Very High
INFLAMMATION 232 97.28 Very High Very High Very High
Experimental Arthritis 224 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, higher levels of CALM1 expression in hip and knee OA cartilage than in normal were also observed [7].
Gene_expression (expression) of CALM1 in cartilage associated with osteoarthritis
1) Confidence 0.71 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2576056 Disease Relevance 0.67 Pain Relevance 0.30
We found that most patients found their CAM to be of help (p = 0.005).
Gene_expression (found) of CAM associated with complementary and alternative medicine
2) Confidence 0.59 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2375857 Disease Relevance 0.16 Pain Relevance 0.52
Orthodox practitioners should be aware that their patients may be using CAM and should routinely enquire about this during consultation.
Gene_expression (using) of CAM associated with complementary and alternative medicine
3) Confidence 0.59 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2375857 Disease Relevance 0.45 Pain Relevance 0.31
Patterns and Reasons of CAM use
Gene_expression (use) of CAM associated with complementary and alternative medicine
4) Confidence 0.59 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2375857 Disease Relevance 0 Pain Relevance 0.32
Negative attention has been called to CAM in a safety perspective because of the unregulated nature of many CAM products and providers in many countries (WHO, 2002).
Gene_expression (products) of CAM associated with complementary and alternative medicine
5) Confidence 0.58 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.38 Pain Relevance 0.44
The process of choosing CAM
Gene_expression (process) of CAM associated with complementary and alternative medicine
6) Confidence 0.58 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.59 Pain Relevance 0.38
One important reason both for Anna and Mona to choose CAM was that they had experienced severe side effects from the conventional treatments which they had been given.
Gene_expression (choose) of CAM associated with complementary and alternative medicine
7) Confidence 0.58 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.46 Pain Relevance 0.39
In the Norwegian context, a recent study among the general population shows that, “over the previous 12 months”, 48.7% of the respondents had received CAM by CAM practitioners outside of or by health care personnel inside the health care system.
Gene_expression (practitioners) of CAM associated with complementary and alternative medicine
8) Confidence 0.58 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.26 Pain Relevance 0.63
Several potential risks related to patients’ choice and use of CAM have been described in the literature: for example, contamination and negative interactions between herbal products and pharmaceuticals (Bjelakovic, Nikolova, Gluud, Simonetti, & Gluud, 2007); refusal of important conventional treatment and delay of diagnosis (Malik & Gopalan, 2003); CAM as an economical burden (Utian, 2005); and problematic notions of self-healing and hyper-positivity (Broom, 2009).
Gene_expression (products) of CAM associated with complementary and alternative medicine
9) Confidence 0.58 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.34 Pain Relevance 0.39
Furthermore, we argue that there is a need for more research on MS and coping among patients using CAM, because these patients’ coping strategies as we have seen in this study can be different from coping strategies among MS patients that are not using CAM.
Neg (not) Gene_expression (using) of CAM associated with complementary and alternative medicine and multiple sclerosis
10) Confidence 0.58 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.78 Pain Relevance 0.50
In Norway where this study was conducted, CAM can be provided either by a CAM practitioner operating outside of the government-funded health care system or by licensed health personnel (Fønnebø & Launsø, 2009; WHO, 2009).
Gene_expression (provided) of CAM associated with complementary and alternative medicine
11) Confidence 0.58 Published 2010 Journal International Journal of Qualitative Studies on Health and Well-being Section Body Doc Link PMC2900149 Disease Relevance 0.47 Pain Relevance 0.59
The well clarified role Ca2+-calmodulin signal played in chondrogenesis and normal cartilage phenotype maintaining, together with the results of the microarray analysis [7] showing higher levels of CALM1 expression both in hip and knee OA, have interested us in assessing whether this genetic polymorphism is also associated with OA in a Chinese Han population.
Gene_expression (expression) of CALM1 in knee associated with osteoarthritis
12) Confidence 0.55 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2576056 Disease Relevance 0.56 Pain Relevance 0.25
CAM also has been shown to produce depression of acetylcholine release from the cat lateral cerebral ventricle similarly to morphine, in a naloxone reversible manner, regardless the applied stimulus (electrical stimulation of sciatic nerve, or ouabain perfusion).
Gene_expression (produce) of CAM in sciatic nerve associated with depression, narcan, sciatic nerve and morphine
13) Confidence 0.53 Published 1988 Journal Pol J Pharmacol Pharm Section Abstract Doc Link 2855884 Disease Relevance 0.10 Pain Relevance 1.28
Thus, there is a need to systematically study and define the mechanisms underlying the activity of CAM products that have been used for the treatment of rheumatic diseases in folk medicine around the world for centuries.
Gene_expression (products) of CAM associated with complementary and alternative medicine and rheumatic diseases
14) Confidence 0.25 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206370 Disease Relevance 1.07 Pain Relevance 0.53
The well clarified role Ca2+-calmodulin signal played in chondrogenesis and normal cartilage phenotype maintaining, together with the results of the microarray analysis [7] showing higher levels of CALM1 expression both in hip and knee OA, have interested us in assessing whether this genetic polymorphism is also associated with OA in a Chinese Han population.
Gene_expression (expression) of CALM1 in hip associated with osteoarthritis
15) Confidence 0.19 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2576056 Disease Relevance 0.56 Pain Relevance 0.25
However, despite the increasing usage and popularity of CAM products in the western world [11, 22–26], one of the main limitations of their use is the meager information about their mechanisms of action and objectivity in evaluating efficacy [27, 28].
Gene_expression (products) of CAM associated with complementary and alternative medicine
16) Confidence 0.18 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC3014691 Disease Relevance 0.92 Pain Relevance 0.80
Thus, study of the levels of expression of different chemokines and adhesion molecules, and the blockade of these biomolecules by appropriate reagents can serve as an important tool for defining the mechanisms of actions of CAM products that have antiarthritic activity.
Gene_expression (products) of CAM associated with complementary and alternative medicine, chemokine and adhesions
17) Confidence 0.15 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC3014691 Disease Relevance 0.75 Pain Relevance 0.75
The expression of calmodulin 1 (CaM1) and calmodulin 2 (CaM2) were down-regulated (?
Gene_expression (expression) of calmodulin 1
18) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.32 Pain Relevance 0.10
A variety of herbal CAM products have been shown to attenuate the severity of the disease in the rat AA model (Table 1).
Gene_expression (products) of CAM associated with complementary and alternative medicine, disease and arthritis
19) Confidence 0.13 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC3014691 Disease Relevance 1.22 Pain Relevance 0.48
We recommend that these and other customized immune parameters be considered for testing besides various biochemical and pharmacological parameters for the evaluation of the mechanisms of action of herbal CAM products.
Gene_expression (products) of CAM associated with complementary and alternative medicine
20) Confidence 0.13 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC3014691 Disease Relevance 1.06 Pain Relevance 0.70

General Comments

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