INT301185

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.73
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (UCP2) mitochondrion (UCP2) small molecule metabolic process (UCP2)
UCP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 12 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 102 98.72 Very High Very High Very High
Diabetes Mellitus 258 79.04 Quite High
Nicotine Addiction 21 76.40 Quite High
Metabolic Syndrome 15 64.48 Quite High
Apoptosis 3 44.48 Quite Low
Cardiovascular Disease 6 43.68 Quite Low
Prediabetic State 9 22.96 Low Low
Coronary Artery Disease 24 22.56 Low Low
Aging 30 5.00 Very Low Very Low Very Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To maintain homeostasis, UCP2 expression is induced by elevated oxygen species concentration [21].
Positive_regulation (induced) of Gene_expression (expression) of UCP2
1) Confidence 0.69 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 0.90 Pain Relevance 0
A common functional variant exists in the promoter of human UCP2 gene (?
Positive_regulation (exists) of Gene_expression (gene) of UCP2
2) Confidence 0.50 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 0.95 Pain Relevance 0
Decreased UCP2 expression results in increased ROS production, in vitro [19], while animal studies have shown that absence of UCP2 causes higher oxidative stress [20].
Positive_regulation (results) of Gene_expression (expression) of UCP2 associated with stress
3) Confidence 0.50 Published 2010 Journal Atherosclerosis Section Body Doc Link PMC2839074 Disease Relevance 0.87 Pain Relevance 0

General Comments

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