INT301209

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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Mir29a (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 280 100.00 Very High Very High Very High
Myelodysplastic Syndromes 5 98.76 Very High Very High Very High
Myeloproliferative Disorder 110 97.56 Very High Very High Very High
Hematologic Neoplasms 10 95.72 Very High Very High Very High
Apoptosis 15 90.80 High High
Starvation 5 87.60 High High
Leukemia 85 87.44 High High
Disease 40 85.32 High High
Breast Cancer 10 83.20 Quite High
Targeted Disruption 10 74.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our gene array expression studies revealed decreased expression of HBP1, Slfn4, Dnmt3L, and Cdc42ep2 in miR-29a mutant cells compared with WT controls, and HBP1 appeared to be one of the authentic targets of miR-29a.
Positive_regulation (targets) of miR-29a
1) Confidence 0.11 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.71 Pain Relevance 0
At present, the mRNA targets required for miR-29a’s biological activities remain unclear.
Positive_regulation (required) of miR-29a
2) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.88 Pain Relevance 0
Although phenotypic MPPs were not detectable in the recipients that received miR-29a–overexpressing MPPs 4 mo after the transplantation, CMP and/or GMP were persistent in these mice for at least up to 6 mo (unpublished data).
Positive_regulation (received) of miR-29a
3) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.11 Pain Relevance 0
Consistently, the proliferation rate of miR-29a–overexpressing 293T cells was significantly enhanced when compared with WT cells (Fig. 5 c).
Positive_regulation (enhanced) of miR-29a
4) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.39 Pain Relevance 0
Compared with CMP, miR-29a expression levels in AML samples (both LSC and non-LSC blast populations) were significantly increased (at least threefold, q < 0.01; Fig. 1, a and b).
Positive_regulation (increased) of miR-29a associated with myeloid leukemia
5) Confidence 0.09 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.85 Pain Relevance 0

General Comments

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