INT301210

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mvd) lyase activity (Mvd) peroxisome (Mvd)
kinase activity (Mvd)
Anatomy Link Frequency
myeloid progenitor cells 1
Mvd (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloproliferative Disorder 88 100.00 Very High Very High Very High
Disease Progression 4 99.96 Very High Very High Very High
Myeloid Leukemia 224 99.04 Very High Very High Very High
Leukemia 68 94.80 High High
Hematological Disease 24 79.96 Quite High
Disease 32 44.52 Quite Low
Splenomegaly 4 15.28 Low Low
Cancer 28 13.88 Low Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We sorted MPP, CMP, and GMP from control (WT or empty retrovirus–transduced chimeric mice) or miR-29a–overexpressing primary chimeric mice before MPD development (?
Gene_expression (development) of MPD associated with myeloproliferative disorder
1) Confidence 0.19 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.27 Pain Relevance 0
Overexpression of miR-29a in hematopoietic progenitors leads to biased myelopoiesis and an MPD
Gene_expression (myelopoiesis) of MPD associated with myeloproliferative disorder
2) Confidence 0.19 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.10 Pain Relevance 0
Overall, these data indicate that the appearance of self-renewing miR-29a–expressing myeloid progenitor cells precedes MPD disease progression to AML, suggesting that aberrant acquisition of self-renewal by myeloid progenitors may be an early event during myeloid leukemogenesis.


Gene_expression (expressing) of MPD in myeloid progenitor cells associated with myeloproliferative disorder, myeloid leukemia and disease progression
3) Confidence 0.19 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.82 Pain Relevance 0
S5 summarizes the transplant data and illustrates the histological changes in miR-29a–expressing MPD mice.
Gene_expression (expressing) of MPD associated with myeloproliferative disorder
4) Confidence 0.17 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.28 Pain Relevance 0

General Comments

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