INT301222

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
granulocytes 1
Mir29a (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 112 94.42 High High
Starvation 2 87.08 High High
Apoptosis 6 85.96 High High
Myelodysplastic Syndromes 2 84.40 Quite High
Myeloproliferative Disorder 44 83.20 Quite High
Cancer 14 82.72 Quite High
Hematologic Neoplasms 4 81.36 Quite High
Disease 16 70.96 Quite High
Leukemia 34 65.28 Quite High
Breast Cancer 4 61.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As miRNAs exert their biological effect by regulating mRNA degradation and/or protein translation, we sought to identify mRNA targets of miR-29a by comparing mRNA expression in sorted Mac-1+ Gr-1+ cells from WT mice and miR-29a overexpressing primary chimeras by mRNA gene expression array.
Transcription (targets) of miR-29a
1) Confidence 0.15 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.34 Pain Relevance 0
Self-renewal of AML stem cells and leukemic transformation has been previously linked to the lipid phosphatase PTEN (Yilmaz et al., 2006), which is predicted by some target prediction algorithms as a target of miR-29a (Lewis et al., 2005; Grimson et al., 2007); however, PTEN protein and mRNA were expressed at equivalent levels in WT and miR-29a┬ľoverexpressing Mac-1+ Gr-1+ granulocytes (unpublished data).
Transcription (expressed) of miR-29a in granulocytes associated with myeloid leukemia
2) Confidence 0.13 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.82 Pain Relevance 0

General Comments

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