INT301228

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 25
Disease Relevance 13.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hematopoietic system 2
Mir29a (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 25 5.00 Very Low Very Low Very Low
isoflurane 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 425 99.96 Very High Very High Very High
Myeloid Leukemia 1400 99.76 Very High Very High Very High
Myeloproliferative Disorder 550 99.32 Very High Very High Very High
Apoptosis 75 99.20 Very High Very High Very High
Targeted Disruption 50 98.00 Very High Very High Very High
Starvation 25 97.60 Very High Very High Very High
Disease 200 94.76 High High
Disease Progression 25 94.44 High High
Hematologic Neoplasms 50 92.32 High High
Breast Cancer 50 91.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of miR-29a in hematopoietic progenitors leads to biased myelopoiesis and an MPD
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of miR-29a associated with myeloproliferative disorder
1) Confidence 0.16 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.10 Pain Relevance 0
Overexpression of miR-29a enhances proliferation of MPP and 293T cells but does not significantly alter MPP self-renewal, yet overexpression of miR-29a in CMP or GMP is sufficient to induce self-renewal but not proliferation, suggesting that miR-29a exerts stage-specific and cell context–specific effects.
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-29a
2) Confidence 0.16 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.38 Pain Relevance 0
To determine whether miR-29a positively regulates cell cycle progression, and given that it is difficult to efficiently infect primary myeloid progenitors with retroviral vector, we compared the G1 to S/G2 phase transition between WT 293T and 293T cells overexpressing miR-29a by in vitro BrdU incorporation assays.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of miR-29a
3) Confidence 0.16 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.45 Pain Relevance 0
Overexpression of miR-29a enhances proliferation of MPP and 293T cells but does not significantly alter MPP self-renewal, yet overexpression of miR-29a in CMP or GMP is sufficient to induce self-renewal but not proliferation, suggesting that miR-29a exerts stage-specific and cell context–specific effects.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of miR-29a
4) Confidence 0.16 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.41 Pain Relevance 0
Nevertheless, because self-renewal is normally a unique feature of HSC and high levels of miR-29a expression are associated with HSC and AML, we hypothesize that miR-29a contributes to HSC and LSC self-renewal.
Positive_regulation (levels) of Gene_expression (expression) of miR-29a associated with myeloid leukemia
5) Confidence 0.16 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.71 Pain Relevance 0
However, further experiments will be required to completely exclude other possible explanations for the long-term engraftment of miR-29a–expressing myeloid progenitors, including that long-term engrafted miR-29a–overexpressing CMP and GMP represent the progeny of rare engrafted HSC exhibiting a strongly biased myeloid differentiation potential, and that the transplanted and/or engrafted immunophenotypic myeloid progenitors may represent abnormal HSC with altered surface marker expression.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of miR-29a
6) Confidence 0.14 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.68 Pain Relevance 0
Enforced miR-29a expression leads to a high incidence of AML
Positive_regulation (Enforced) of Gene_expression (expression) of miR-29a associated with myeloid leukemia
7) Confidence 0.14 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.46 Pain Relevance 0
Given the dramatic phenotype induced by miR-29a overexpression, it is likely that miR-29a targets multiple mRNAs in addition to HBP1 to induce the described phenotypes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-29a
8) Confidence 0.11 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.30 Pain Relevance 0
Although shRNA knock-down of HBP1 in mouse progenitors did not recapitulate the myeloid proliferation or AML induced by miR-29 overexpression, a coordinating role of HBP1 with other factors such as Slfn4, Dnmt3L, and Cdc42ep2 in leukemic development cannot be excluded.
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-29 associated with targeted disruption and myeloid leukemia
9) Confidence 0.11 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.60 Pain Relevance 0
In contrast, our data support the model that in miR-29a–induced leukemia, overexpression of miR-29a leads to aberrant acquisition of self-renewal capability by committed progenitors before the establishment of the MPD phase of the disease.
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-29a associated with myeloproliferative disorder, leukemia and disease
10) Confidence 0.11 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.88 Pain Relevance 0
There was no apparent effect of miR-29a overexpression on basal levels of apoptosis or apoptosis induced by serum starvation, suggesting that ectopic expression of miR-29a does not exhibit a significant impact on cell survival (unpublished data).


Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-29a associated with starvation and apoptosis
11) Confidence 0.11 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.41 Pain Relevance 0
Because overexpression of miR-29a induces mouse AML, we decided to examine whether miR-29a is also overexpressed in human AML.
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-29a associated with myeloid leukemia
12) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.74 Pain Relevance 0
Moreover, overexpression of miR-29a converts short-lived myeloid progenitors into self-renewing cells before the development of AML.
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-29a associated with myeloid leukemia
13) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.68 Pain Relevance 0
Consistent with function as a bona fide oncogene, miR-29a overexpression results in the development of an MPD that progresses to AML.
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-29a associated with myeloproliferative disorder and myeloid leukemia
14) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.75 Pain Relevance 0
As high levels of miR-29a expression are also present in human AML, it will be of great interest to determine whether miR-29a may serve as a potential target for AML therapy.


Positive_regulation (levels) of Gene_expression (expression) of miR-29a associated with myeloid leukemia
15) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.48 Pain Relevance 0
Overexpression of miR-29a in the hematopoietic system results in biased myeloid lineage development and development of a myeloproliferative disorder (MPD) that progresses to AML.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of miR-29a in hematopoietic system associated with myeloproliferative disorder and myeloid leukemia
16) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.69 Pain Relevance 0
Together, these data indicate that overexpression of miR-29a significantly affects hematopoietic development by altering myeloid progenitor composition and promoting myeloid differentiation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of miR-29a
17) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.24 Pain Relevance 0
Consistently, the proliferation rate of miR-29a–overexpressing 293T cells was significantly enhanced when compared with WT cells (Fig. 5 c).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of miR-29a
18) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.39 Pain Relevance 0
However, further experiments will be required to completely exclude other possible explanations for the long-term engraftment of miR-29a–expressing myeloid progenitors, including that long-term engrafted miR-29a–overexpressing CMP and GMP represent the progeny of rare engrafted HSC exhibiting a strongly biased myeloid differentiation potential, and that the transplanted and/or engrafted immunophenotypic myeloid progenitors may represent abnormal HSC with altered surface marker expression.
Positive_regulation (overexpressing) of Gene_expression (expressing) of miR-29a
19) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.76 Pain Relevance 0
Because aberrant acquisition of self-renewal capacity is likely an important step in myeloid leukemogenesis (Passegué et al., 2003), we sought to determine whether miR-29a–overexpressing progenitors acquire this capacity during the early phase of MPD.
Spec (whether) Positive_regulation (overexpressing) of Spec (whether) Gene_expression (overexpressing) of miR-29a associated with myeloproliferative disorder
20) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.27 Pain Relevance 0

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