INT301232

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Matn1) proteinaceous extracellular matrix (Matn1)
Matn1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 91.44 High High
Myeloproliferative Disorder 44 90.60 High High
Myeloid Leukemia 112 88.48 High High
Targeted Disruption 4 84.96 Quite High
Leukemia 34 84.80 Quite High
Breast Cancer 4 80.76 Quite High
Chronic Myeloid Leukemia 2 74.60 Quite High
Myelodysplastic Syndromes 2 43.24 Quite Low
Hematologic Neoplasms 4 40.20 Quite Low
Cancer 14 14.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of miR-29a enhances proliferation of MPP and 293T cells but does not significantly alter MPP self-renewal, yet overexpression of miR-29a in CMP or GMP is sufficient to induce self-renewal but not proliferation, suggesting that miR-29a exerts stage-specific and cell context–specific effects.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CMP
1) Confidence 0.07 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.39 Pain Relevance 0
However, further experiments will be required to completely exclude other possible explanations for the long-term engraftment of miR-29a–expressing myeloid progenitors, including that long-term engrafted miR-29a–overexpressing CMP and GMP represent the progeny of rare engrafted HSC exhibiting a strongly biased myeloid differentiation potential, and that the transplanted and/or engrafted immunophenotypic myeloid progenitors may represent abnormal HSC with altered surface marker expression.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of CMP
2) Confidence 0.07 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.68 Pain Relevance 0

General Comments

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