INT301233

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.36
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cdc42ep2) cytoskeleton (Cdc42ep2) cytoplasm (Cdc42ep2)
Cdc42ep2 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 14 85.52 High High
Myeloid Leukemia 112 82.72 Quite High
Breast Cancer 4 82.24 Quite High
Myelodysplastic Syndromes 2 78.28 Quite High
Leukemia 34 78.24 Quite High
Myeloproliferative Disorder 44 77.08 Quite High
Hematologic Neoplasms 4 75.24 Quite High
Targeted Disruption 4 64.96 Quite High
Disease 16 64.84 Quite High
Starvation 2 63.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with being physiological targets of miR-29a, decreased expression was confirmed for a subset of the genes by Western blot or semiquantitative PCR analyses, including Cdc42ep2, Slfn4, and HBP1 (Fig. 6, b and c, and Fig.
Negative_regulation (decreased) of Gene_expression (expression) of Cdc42ep2
1) Confidence 0.24 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.55 Pain Relevance 0
Our gene array expression studies revealed decreased expression of HBP1, Slfn4, Dnmt3L, and Cdc42ep2 in miR-29a mutant cells compared with WT controls, and HBP1 appeared to be one of the authentic targets of miR-29a.
Negative_regulation (decreased) of Gene_expression (expression) of Cdc42ep2
2) Confidence 0.24 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.81 Pain Relevance 0

General Comments

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