INT301238

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.39
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx1) DNA binding (Runx1) transcription factor binding (Runx1)
Mir29a (Mus musculus)
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 112 100.00 Very High Very High Very High
Targeted Disruption 4 98.30 Very High Very High Very High
Breast Cancer 4 92.40 High High
Leukemia 34 90.08 High High
Disease 16 88.96 High High
Myelodysplastic Syndromes 2 54.88 Quite High
Myeloproliferative Disorder 44 53.68 Quite High
Hematologic Neoplasms 4 51.84 Quite High
Disease Progression 2 22.60 Low Low
Malignant Neoplastic Disease 6 20.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although shRNA knock-down of HBP1 in mouse progenitors did not recapitulate the myeloid proliferation or AML induced by miR-29 overexpression, a coordinating role of HBP1 with other factors such as Slfn4, Dnmt3L, and Cdc42ep2 in leukemic development cannot be excluded.
Gene_expression (overexpression) of miR-29 Neg (not) Positive_regulation (induced) of AML associated with targeted disruption and myeloid leukemia
1) Confidence 0.00 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.60 Pain Relevance 0
Because overexpression of miR-29a induces mouse AML, we decided to examine whether miR-29a is also overexpressed in human AML.
Gene_expression (overexpression) of miR-29a Positive_regulation (induces) of AML associated with myeloid leukemia
2) Confidence 0.00 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.79 Pain Relevance 0

General Comments

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