INT301246

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HMGB1, Hbp1) DNA binding (HMGB1, Hbp1) nucleoplasm (HMGB1)
extracellular space (HMGB1) extracellular region (HMGB1) nucleolus (HMGB1)
HMGB1 (Homo sapiens)
Hbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 17 95.88 Very High Very High Very High
Breast Cancer 2 93.76 High High
Targeted Disruption 2 78.48 Quite High
Myeloid Leukemia 56 75.76 Quite High
Myelodysplastic Syndromes 1 71.32 Quite High
Myeloproliferative Disorder 22 70.12 Quite High
Hematologic Neoplasms 2 68.28 Quite High
Disease 8 57.88 Quite High
Malignant Neoplastic Disease 3 37.28 Quite Low
Lifespan 1 32.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HBP1 is a high mobility group protein that interacts with and is transcriptionally regulated by Rb, functionally inhibits G1 to G2/S phase cell cycling in leukemia cell lines, and is associated with invasive breast cancer (Tevosian et al., 1997; Shih et al., 1998; Yao et al., 2005; Paulson et al., 2007).
high mobility group protein Binding (interacts) of HBP1 associated with leukemia and breast cancer
1) Confidence 0.03 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.74 Pain Relevance 0

General Comments

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