INT301262

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 3.01
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Clec5a)
Anatomy Link Frequency
joint 6
Clec5a (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 32 98.96 Very High Very High Very High
Inflammation 144 97.48 Very High Very High Very High
Arthritis 148 97.08 Very High Very High Very High
agonist 80 68.40 Quite High
cytokine 28 18.20 Low Low
Pain 8 12.24 Low Low
antagonist 16 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 88 99.92 Very High Very High Very High
Rheumatoid Arthritis 32 98.96 Very High Very High Very High
Arthritis 212 97.72 Very High Very High Very High
INFLAMMATION 120 96.80 Very High Very High Very High
Injury 8 91.96 High High
Hypercalcemia 28 84.72 Quite High
Arthropathy 20 83.76 Quite High
Bone Cancer 8 78.56 Quite High
Congenital Anomalies 4 72.80 Quite High
Osteoporosis 8 61.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Functional blockade of MDL-1 receptor via Mdl1 deletion or treatment with MDL-1-Ig fusion protein reduces the clinical signs of autoimmune joint inflammation.
Negative_regulation (blockade) of Gene_expression (deletion) of MDL-1-Ig in joint associated with inflammation and arthritis
1) Confidence 0.43 Published 2010 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2839155 Disease Relevance 0.59 Pain Relevance 0.21
Functional blockade of MDL-1 receptor via Mdl1 deletion or treatment with MDL-1-Ig fusion protein reduces the clinical signs of autoimmune joint inflammation.
Negative_regulation (blockade) of Gene_expression (deletion) of Mdl1 in joint associated with inflammation and arthritis
2) Confidence 0.43 Published 2010 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2839155 Disease Relevance 0.59 Pain Relevance 0.21
We have bridged the findings in our mouse studies to human diseases by demonstrating human MDL-1 expression in synovial tissues from RA patients.
Negative_regulation (demonstrating) of Gene_expression (expression) of MDL-1 associated with rheumatoid arthritis and disease
3) Confidence 0.43 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 1.24 Pain Relevance 0.38
Functional blockade of MDL-1 receptor via Mdl1 deletion or treatment with MDL-1-Ig fusion protein reduces the clinical signs of autoimmune joint inflammation.
Negative_regulation (blockade) of Gene_expression (deletion) of MDL-1 receptor in joint associated with inflammation and arthritis
4) Confidence 0.43 Published 2010 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2839155 Disease Relevance 0.59 Pain Relevance 0.21

General Comments

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