INT301263

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Context Info
Confidence 0.77
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 14.64
Pain Relevance 5.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Clec5a)
Anatomy Link Frequency
joint 5
macrophages 4
myeloid cells 2
neutrophils 2
osteoclast 1
Clec5a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 788 99.84 Very High Very High Very High
rheumatoid arthritis 168 98.96 Very High Very High Very High
cytokine 171 98.84 Very High Very High Very High
Arthritis 777 98.52 Very High Very High Very High
Inflammatory response 42 97.52 Very High Very High Very High
agonist 420 86.64 High High
Pain 44 70.56 Quite High
Inflammatory mediators 21 58.48 Quite High
antagonist 84 20.96 Low Low
imagery 63 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 662 99.84 Very High Very High Very High
Arthritis 1113 99.56 Very High Very High Very High
Disease 466 99.52 Very High Very High Very High
Rheumatoid Arthritis 168 98.96 Very High Very High Very High
Hypercalcemia 147 97.00 Very High Very High Very High
Pressure And Volume Under Development 189 96.32 Very High Very High Very High
Infection 220 96.04 Very High Very High Very High
Congenital Anomalies 21 94.12 High High
Injury 44 91.48 High High
Mycobacterial Infection 290 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have bridged the findings in our mouse studies to human diseases by demonstrating human MDL-1 expression in synovial tissues from RA patients.
Gene_expression (expression) of MDL-1 associated with rheumatoid arthritis and disease
1) Confidence 0.77 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 1.23 Pain Relevance 0.37
MDL-1—a C-type lectin domain family 5, member A (CLEC5A)—is highly expressed on TNF-activated macrophages (Bakker et al., 1999).
Gene_expression (expressed) of MDL-1 in macrophages
2) Confidence 0.77 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.48 Pain Relevance 0.19
, IL-6, and IL-17 are suppressed in MDL-1–Ig fusion protein–treated mice, whereas the anti–MDL-1–treated group show enhanced cytokine gene expression (Fig. 5 A).
Gene_expression (suppressed) of MDL-1 associated with cytokine
3) Confidence 0.67 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.41 Pain Relevance 0.29
Functional blockade of MDL-1 receptor via Mdl1 deletion or treatment with MDL-1-Ig fusion protein reduces the clinical signs of autoimmune joint inflammation.
Gene_expression (deletion) of Mdl1 in joint associated with inflammation and arthritis
4) Confidence 0.67 Published 2010 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2839155 Disease Relevance 0.59 Pain Relevance 0.21
Depletion of circulating granulocytes and/or monocytes significantly reduces MDL-1–dependent joint inflammation during CAIA, suggesting that inflammatory macrophages and neutrophils play a key role in MDL-1–mediated pathology.
Gene_expression (reduces) of MDL-1 in joint associated with inflammation and arthritis
5) Confidence 0.67 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.78 Pain Relevance 0.28
Functional blockade of MDL-1 receptor via Mdl1 deletion or treatment with MDL-1-Ig fusion protein reduces the clinical signs of autoimmune joint inflammation.
Gene_expression (deletion) of MDL-1 receptor in joint associated with inflammation and arthritis
6) Confidence 0.67 Published 2010 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2839155 Disease Relevance 0.59 Pain Relevance 0.21
Cross-linking cell surface MDL-1 receptors induces DAP12-ITAM–dependent calcium mobilization (Bakker et al., 1999) and activation of the Syk and phospholipase C?
Gene_expression (receptors) of MDL-1
7) Confidence 0.67 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.26 Pain Relevance 0.10
Functional blockade of MDL-1 receptor via Mdl1 deletion or treatment with MDL-1-Ig fusion protein reduces the clinical signs of autoimmune joint inflammation.
Gene_expression (deletion) of MDL-1-Ig in joint associated with inflammation and arthritis
8) Confidence 0.67 Published 2010 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2839155 Disease Relevance 0.59 Pain Relevance 0.21
MDL-1—a C-type lectin domain family 5, member A (CLEC5A)—is highly expressed on TNF-activated macrophages (Bakker et al., 1999).
Gene_expression (expressed) of CLEC5A in macrophages
9) Confidence 0.67 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.47 Pain Relevance 0.18
, IL-6, and IL-17 are suppressed in MDL-1–Ig fusion protein–treated mice, whereas the anti–MDL-1–treated group show enhanced cytokine gene expression (Fig. 5 A).
Gene_expression (suppressed) of MDL-1-Ig associated with cytokine
10) Confidence 0.67 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.40 Pain Relevance 0.28
The apparent regulation of the TRAP, RANKL, ATPV0D2, and MMP9 expression after anti–MDL-1 treatment suggests MDL-1 receptor activation may promote osteoclast development and function.
Gene_expression (expression) of MDL-1 in osteoclast
11) Confidence 0.67 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.23 Pain Relevance 0.18
Interestingly, most, but not all, of the CD11b+ cells also coexpress MDL-1 as shown in the merged immunofluorescent images, which appeared yellow (Fig.
Gene_expression (coexpress) of MDL-1
12) Confidence 0.60 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.74 Pain Relevance 0.34
Correspondingly, MDL-1 protein is expressed on murine granulocytes (CD11b+ Ly6G+) and monocytes (CD11b+ Ly6G?)
Gene_expression (expressed) of MDL-1 protein in granulocytes
13) Confidence 0.60 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.42 Pain Relevance 0.21
, further enhances Mdl1 mRNA and protein expression in bone marrow–derived macrophage colony-stimulating factor (MCSF)-dependent macrophages (Fig. 1 D).
Gene_expression (expression) of Mdl1 in macrophage
14) Confidence 0.60 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.33 Pain Relevance 0.16
MDL-1 receptor is expressed on bone marrow cells and inflamed joints
Gene_expression (expressed) of MDL-1 receptor in joints
15) Confidence 0.60 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.49 Pain Relevance 0.24
In this study, we demonstrate that MDL-1 is expressed on inflammatory macrophages and neutrophils, as well as bone marrow–derived osteoclast precursors.
Gene_expression (expressed) of MDL-1 in neutrophils associated with inflammation
16) Confidence 0.60 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.55 Pain Relevance 0.27
This is consistent with our observation that MDL-1 expression on myeloid cells is enhanced by TNF but not IFN-?
Gene_expression (expression) of MDL-1 in myeloid cells
17) Confidence 0.60 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.92 Pain Relevance 0.26
Given the expression pattern of MDL-1 in joint tissues, we examined its expression on leukocytes during a collagen antibody-induced arthritis (CAIA) model.
Gene_expression (expression) of MDL-1 in leukocytes associated with arthritis
18) Confidence 0.60 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.83 Pain Relevance 0.40
Although MDL-1 expression is up-regulated in activated myeloid cells, it is not known whether this receptor plays any role in autoimmune inflammation.
Gene_expression (expression) of MDL-1 in myeloid cells associated with inflammation
19) Confidence 0.60 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.37 Pain Relevance 0.18
There are at least 15 known DAP12-associating cell surface receptors with distinct temporal and cell type–specific expression patterns.
Gene_expression (expression) of DAP12-associating
20) Confidence 0.59 Published 2010 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2839155 Disease Relevance 0.49 Pain Relevance 0.16

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