INT301269

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.28
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Clec5a)
Anatomy Link Frequency
osteoclasts 4
Clec5a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 72 89.48 High High
Arthritis 74 88.28 High High
agonist 40 87.20 High High
cytokine 14 66.40 Quite High
antagonist 8 49.24 Quite Low
Pain 4 14.88 Low Low
rheumatoid arthritis 16 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 44 98.52 Very High Very High Very High
Hypercalcemia 14 95.72 Very High Very High Very High
Pressure And Volume Under Development 18 95.08 Very High Very High Very High
INFLAMMATION 60 89.48 High High
Arthritis 106 88.28 High High
Bone Cancer 4 73.04 Quite High
Arthropathy 10 68.00 Quite High
Leukoencephalopathies 2 53.04 Quite High
Bone Cysts 2 21.44 Low Low
Pain 2 14.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By testing serum samples during the course of disease, we found that the osteoclast-specific TRAP 5b levels were significantly increased after MDL-1 receptor activation (Fig. 4 C).
Positive_regulation (increased) of Positive_regulation (activation) of MDL-1 receptor in osteoclast associated with disease
1) Confidence 0.50 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.34 Pain Relevance 0.18
We also demonstrate that MDL-1 activation increases the expression of NFATc1 and ATPV0D2, which control cell fusion (Lee et al., 2006), as well as regulating bone resorption via TRAP and cathepsin K in osteoclasts (Takayanagi, 2005a).
Positive_regulation (increases) of Positive_regulation (activation) of MDL-1 in osteoclasts associated with hypercalcemia
2) Confidence 0.50 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.94 Pain Relevance 0.28

General Comments

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