INT30128

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Context Info
Confidence 0.06
First Reported 1988
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.18
Pain Relevance 1.25

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signal transduction (MET, Gast) cell proliferation (MET) extracellular region (Gast)
plasma membrane (MET)
Anatomy Link Frequency
CER 2
MET (Homo sapiens)
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 20 100.00 Very High Very High Very High
Central nervous system 2 90.24 High High
opiate 2 75.00 Quite High
Enkephalin 2 75.00 Quite High
Neuropeptide 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Gallbladder Disease 2 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, two other very similar peptides, the last four residues of CCK (CCK-4) whose sequence is Trp-Met-Asp-Phe-NH2, and the carboxyl terminal hexapeptide of little gastrin (LGA-6, Tyr-Gly-Trp-Met-Asp-Phe-NH2, i.e., residue 2 deleted relative to CCK-7 and CER-7 sequences), interact specifically with gastrin receptors and not at all or very weakly with peripheral receptors.
Met Binding (interact) of gastrin in CER associated with cholecystokinin
1) Confidence 0.06 Published 1988 Journal Peptides Section Abstract Doc Link 2856638 Disease Relevance 0.09 Pain Relevance 0.63
In contrast, two other very similar peptides, the last four residues of CCK (CCK-4) whose sequence is Trp-Met-Asp-Phe-NH2, and the carboxyl terminal hexapeptide of little gastrin (LGA-6, Tyr-Gly-Trp-Met-Asp-Phe-NH2, i.e., residue 2 deleted relative to CCK-7 and CER-7 sequences), interact specifically with gastrin receptors and not at all or very weakly with peripheral receptors.
Met Binding (interact) of gastrin in CER associated with cholecystokinin
2) Confidence 0.06 Published 1988 Journal Peptides Section Abstract Doc Link 2856638 Disease Relevance 0.09 Pain Relevance 0.62

General Comments

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