INT301284

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.32
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Tnfsf11, Nfatc1) cell differentiation (Tnfsf11) intracellular (Tnfsf11)
DNA binding (Nfatc1) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
Anatomy Link Frequency
osteoclast 2
Tnfsf11 (Mus musculus)
Nfatc1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 20 78.00 Quite High
Inflammation 36 74.88 Quite High
cytokine 7 29.96 Quite Low
Arthritis 37 27.52 Quite Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 53 75.36 Quite High
Arthropathy 5 68.88 Quite High
Hypercalcemia 7 66.96 Quite High
INFLAMMATION 30 50.00 Quite Low
Pressure And Volume Under Development 9 21.84 Low Low
Disease 22 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Dengue 3 5.00 Very Low Very Low Very Low
Osteoporosis 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MDL-1 + RANKL induced a significant increase of phospho-NFATc1 nuclear localization over RANKL alone, indicating that MDL-1-DAP12–mediated signaling promotes amplification of this transcription regulator required for osteoclast differentiation (Fig. 5 C).
RANKL Positive_regulation (increase) of Localization (localization) of NFATc1 in osteoclast
1) Confidence 0.16 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.32 Pain Relevance 0.11

General Comments

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