INT30131

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Context Info
Confidence 0.50
First Reported 1982
Last Reported 2006
Negated 2
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.94
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
plasma 2
neurohypophysis 2
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 6 100.00 Very High Very High Very High
Clonidine 25 99.98 Very High Very High Very High
agonist 14 98.68 Very High Very High Very High
Opioid 4 96.80 Very High Very High Very High
MU agonist 3 92.96 High High
Neuropeptide 12 87.72 High High
antagonist 11 82.60 Quite High
Morphine 2 82.16 Quite High
narcan 4 74.80 Quite High
Kappa opioid receptor 1 66.80 Quite High
Disease Link Frequency Relevance Heat
Polyuria 1 99.98 Very High Very High Very High
Overactive Bladder 10 99.44 Very High Very High Very High
Congenital Anomalies 1 97.84 Very High Very High Very High
Diuresis 6 94.28 High High
Diabetes Insipidus 4 92.12 High High
Natriuresis 6 83.80 Quite High
Oliguria 1 80.36 Quite High
Hypoxia 1 79.20 Quite High
Reprotox - General 1 2 50.00 Quite Low
Pressure And Volume Under Development 1 37.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data are consistent with the hypothesis that kappa agonists inhibit release of vasopressin from the neurohypophysis and this decrease in vasopressin release leads to increased urination.
Positive_regulation (leads) of Negative_regulation (decrease) of vasopressin in neurohypophysis associated with agonist and overactive bladder
1) Confidence 0.50 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6137557 Disease Relevance 0.95 Pain Relevance 1.09
[Effect of clonidine on polyuria induced by alcohol, water or the lack of vasopressin in the rat].
Positive_regulation (induced) of Negative_regulation (lack) of vasopressin associated with polyuria, alcohol and clonidine
2) Confidence 0.50 Published 1982 Journal J Pharmacol Section Title Doc Link 7154668 Disease Relevance 0.27 Pain Relevance 0.82
Since the diuretic reflex elicited by the hypobaric pressure breathing is due to an inhibition of vasopressin release, the present data show that clonidine induces an inhibition of vasopressin release.
Positive_regulation (induces) of Negative_regulation (inhibition) of vasopressin associated with clonidine
3) Confidence 0.47 Published 1984 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6497501 Disease Relevance 0.38 Pain Relevance 0.66
Progesterone therapy caused an increase in plasma ANF and osmolality levels and the AVP threshold and a decrease in AVP levels and sensitivity and urinary cyclic nucleotide levels.
Positive_regulation (caused) of Negative_regulation (decrease) of AVP in plasma
4) Confidence 0.27 Published 1997 Journal Clin Invest Med Section Body Doc Link 9258576 Disease Relevance 0 Pain Relevance 0
Although the presence of AVP at the level of the SCN may not be critical for the expression of some of the circadian rhythms, abnormalities can be seen in some of the expressed rhythms in its absence.
Neg (not) Positive_regulation (critical) of Negative_regulation (presence) of AVP associated with congenital anomalies
5) Confidence 0.17 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.10 Pain Relevance 0.04
The diuretic effect of clonidine appears to be related to ANF release but not to inhibition of vasopressin.
Neg (not) Spec (appears) Positive_regulation (related) of Negative_regulation (inhibition) of vasopressin associated with clonidine
6) Confidence 0.16 Published 1988 Journal Peptides Section Abstract Doc Link 2856643 Disease Relevance 0.24 Pain Relevance 0.68

General Comments

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