INT301339

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.81
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd59a)
Anatomy Link Frequency
brain 1
Cd59a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 18 100.00 Very High Very High Very High
cytokine 6 92.64 High High
ischemia 56 86.80 High High
Inflammatory response 6 74.48 Quite High
chemokine 2 63.12 Quite High
isoflurane 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 100.00 Very High Very High Very High
Cerebral Edema 14 97.94 Very High Very High Very High
Adhesions 2 94.32 High High
Apoptosis 8 86.96 High High
Cv Unclassified Under Development 18 86.80 High High
Stroke 42 83.20 Quite High
Death 18 71.32 Quite High
Targeted Disruption 30 70.16 Quite High
Middle Cerebral Artery Infarction 84 65.20 Quite High
Brain Injury 10 61.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nevertheless, we did not detect a significant increase of the inflammatory cell accumulation in the CD59a-deficient mice when compared to wild-type mice.
Positive_regulation (increase) of CD59a associated with inflammation
1) Confidence 0.50 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 0.76 Pain Relevance 0.29
Brain swelling correlated with infarct volumes, because brain swelling - as calculated by the size difference of the ischemic and nonischemic hemisphere - was significantly increased in CD59a-/- male mice (median: CD59am-/-: 33 mm3; WTm: 14 mm3) and mixed gender (median: CD59amix-/-: 31 mm3; WTmix: 16 mm3), but not female mice (Figure 2B,D,F).


Positive_regulation (increased) of CD59am in brain associated with cerebral edema
2) Confidence 0.40 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2839971 Disease Relevance 1.05 Pain Relevance 0

General Comments

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