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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Ext1) Golgi apparatus (Ext1) endoplasmic reticulum (Ext1)
Anatomy Link Frequency
growth plate 1
Ext1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteochondroma 40 99.58 Very High Very High Very High
Congenital Anomalies 6 95.72 Very High Very High Very High
Cancer 16 95.56 Very High Very High Very High
Sarcoma 4 66.96 Quite High
Repression 1 64.28 Quite High
Osteoporosis 2 57.20 Quite High
Exostoses 8 54.32 Quite High
Multiple Hereditary Exostoses 55 50.00 Quite Low
Osteopoikilosis 26 50.00 Quite Low
Chondrosarcoma 20 33.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All exons were compared to genomic sequence (NM_014319.3 for LEMD3 gene and NM_000127.2 for EXT1 gene) and variations were numbered according to Ensembl ENSG00000174106 for LEMD3 and ENSG00000182197 for EXT1.
Negative_regulation (numbered) of EXT1
1) Confidence 0.42 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2912259 Disease Relevance 0.11 Pain Relevance 0
Loss of the remaining wild-type allele of EXT1 in hereditary osteochondromas [31] indicated that inactivation of both copies of the EXT1 gene in cartilaginous cells of the growth plate is required for osteochondroma formation, thereby acting as a tumour suppressor gene [31].
Negative_regulation (inactivation) of EXT1 in growth plate associated with cancer and osteochondroma
2) Confidence 0.38 Published 2004 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840003 Disease Relevance 0.98 Pain Relevance 0

General Comments

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