INT301359

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Context Info
Confidence 0.19
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.64
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgfr3) nucleus (Fgfr3) kinase activity (Fgfr3)
cell-cell signaling (Fgfr3) lysosome (Fgfr3) cytoplasm (Fgfr3)
Anatomy Link Frequency
chondrocyte 1
Fgfr3 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 99.40 Very High Very High Very High
Sarcoma 8 93.20 High High
Osteochondroma 80 87.44 High High
Cancer 26 63.68 Quite High
Multiple Hereditary Exostoses 90 50.00 Quite Low
Congenital Anomalies 10 36.00 Quite Low
Osteoarthritis 6 6.76 Low Low
Chondrosarcoma 38 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 34 5.00 Very Low Very Low Very Low
Syndrome 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, activation of FGFR3 in the proliferative zone (Fig. 5), by FGF18 [84] inhibits chondrocyte proliferation via phosphorylation of STAT-1 and subsequent upregulation of p21WAF/CIP1, which can inhibit the cell cycle [85].
Positive_regulation (activation) of FGFR3 in chondrocyte
1) Confidence 0.19 Published 2004 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840003 Disease Relevance 0.23 Pain Relevance 0
FGFR3 activation also leads to repression of IHh signalling [80,81,86].


Positive_regulation (activation) of FGFR3 associated with repression
2) Confidence 0.18 Published 2004 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840003 Disease Relevance 0.41 Pain Relevance 0

General Comments

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