INT30136

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Context Info
Confidence 0.48
First Reported 1985
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 4.31
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (S100A9) cytoplasm (S100A9) signal transducer activity (S100A9)
signal transduction (S100A9) extracellular space (S100A9) extracellular region (S100A9)
Anatomy Link Frequency
neutrophil 3
CLN 2
S100A9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 22 100.00 Very High Very High Very High
Inflammation 121 99.32 Very High Very High Very High
spastic colon 51 99.24 Very High Very High Very High
metalloproteinase 2 99.08 Very High Very High Very High
agonist 30 98.36 Very High Very High Very High
Crohn's disease 1 79.68 Quite High
chemokine 1 25.00 Low Low
antagonist 14 11.36 Low Low
addiction 21 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 127 99.32 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

51 99.24 Very High Very High Very High
Inflammatory Bowel Disease 241 98.46 Very High Very High Very High
Disease 178 98.26 Very High Very High Very High
Hypertension 6 97.96 Very High Very High Very High
Fungal Infection 2 97.44 Very High Very High Very High
Hypotension 2 96.16 Very High Very High Very High
Apoptosis 2 96.08 Very High Very High Very High
Malignant Neoplastic Disease 2 95.56 Very High Very High Very High
Colitis 30 91.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that NIF and CLN do not interact negatively on blood pressure control in essential hypertensive subjects.
NIF Neg (negatively) Binding (interact) of in CLN associated with hypertension and clonidine
1) Confidence 0.48 Published 1985 Journal J Hypertens Suppl Section Abstract Doc Link 2856710 Disease Relevance 0.40 Pain Relevance 0.94
In order to evaluate possible negative interactions between NIF and CLN in man during chronic treatment with these drugs, 12 patients with mild to moderate uncomplicated essential hypertension received either NIF (20 mg twice daily), CLN (0.25 mg once daily), the two drugs together at the same doses, or their matched placebos for a 2-week period each.
NIF Neg (negative) Binding (interactions) of in CLN associated with hypertension and clonidine
2) Confidence 0.37 Published 1985 Journal J Hypertens Suppl Section Abstract Doc Link 2856710 Disease Relevance 0.34 Pain Relevance 0.75
S100A12 binds to the receptor for advanced glycation end-products, while complexes of S100A8/S100A9 (myeloid-related proteins, MRP8/14; calprotectin) are ligands of toll-like receptor 4.
S100A9 Binding (binds) of
3) Confidence 0.35 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18729068 Disease Relevance 0.43 Pain Relevance 0.19
By adding S100A8/S100A9 complexes to a semi-recombinant system comprising bovine neutrophil membranes, cytosolic phox proteins, GTP?
S100A9 Binding (complexes) of in neutrophil
4) Confidence 0.21 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
S100A8/S100A9 complexes facilitate NADPH oxidase activation by transferring arachidonic acid to the NADPH oxidase complex [159].
S100A9 Binding (complexes) of
5) Confidence 0.21 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
By adding S100A8/S100A9 complexes to a semi-recombinant system comprising bovine neutrophil membranes, cytosolic phox proteins, GTP?
S100A9 Binding (adding) of in neutrophil
6) Confidence 0.21 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
In our study of 65 IBD patients (14 CD and 51 UC) and 20 outpatients diagnosed with IBS according to Roma II criteria, fecal calprotectin was found to be strongly associated with colorectal inflammation, indicating the presence of organic disease.48
calprotectin Binding (associated) of associated with inflammatory bowel disease, inflammation, spastic colon and disease
7) Confidence 0.21 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.36 Pain Relevance 0.46
S100A8/S100A9 heterodimers appear to interact preferentially with p67phox and might favor the organization of the cytosolic factors and enhance their recruitment to the membrane-bound flavocytochrome b558, acting as scaffold proteins (Fig. 1).
S100A9 Binding (interact) of
8) Confidence 0.20 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Subsequent to Ca2+ fixation, a heterocomplex is formed by a noncovalent association of Ca2+-binding proteins S100A8 and S100A9 [154, 155].
S100A9 Binding (association) of
9) Confidence 0.20 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
As fMLF stimulation mediates a significant increase in S100A9 localized to the base of lamellipodia and as phosphorylated S100A8/S100A9 associates with F-actin, it can be assumed that phosphorylation results in S100A9 translocation.
S100A9 Binding (associates) of
10) Confidence 0.20 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Subsequent to Ca2+ fixation, a heterocomplex is formed by a noncovalent association of Ca2+-binding proteins S100A8 and S100A9 [154, 155].
S100A9 Binding (binding) of
11) Confidence 0.20 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Calprotectin is a calcium-binding protein that inhibits metalloproteinases, hasantibacterial and antifungal activities and induces apoptosis in malignant and nonmalignant cell cultures.46 Calprotectin constitutes 60% of neutrophil cytosolic proteins and is an abundant protein found in all body fluids in proportion to the degree of inflammation.
Calprotectin Binding (binding) of in neutrophil associated with malignant neoplastic disease, fungal infection, inflammation, metalloproteinase and apoptosis
12) Confidence 0.17 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2827710 Disease Relevance 1.23 Pain Relevance 0.21

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